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PMID: 18819109 Published · ppublish English Journal Article

Hippocampal, amygdala, and neocortical synchronization of theta rhythms is related to an immediate recall during rey auditory verbal learning test.

Human brain mapping ·Vol. 30 ·No. 7 ·2009-07-00 ·Pages 2077-89

Babiloni C, Vecchio F, Mirabella G, Buttiglione M, Sebastiano F, Picardi A, Di Gennaro G, Quarato PP, Grammaldo LG, Buffo P, Esposito V, Manfredi M, Cantore G, Eusebi F

Abstract

It is well known that theta rhythms (3-8 Hz) are the fingerprint of hippocampus, and that neural activity accompanying encoding of words differs according to whether the items are later remembered or forgotten ["subsequent memory effect" (SME)]. Here, we tested the hypothesis that temporal synchronization of theta rhythms among hippocampus, amygdala, and neocortex is related to immediate memorization of repeated words. To address this issue, intracerebral electroencephalographic (EEG) activity was recorded in five subjects with drug-resistant temporal lobe epilepsy (TLE), under presurgical monitoring routine. During the recording of the intracerebral EEG activity, the subjects performed a computerized version of Rey auditory verbal learning test (RAVLT), a popular test for the clinical evaluation of the immediate and delayed memory. They heard the same list of 15 common words for five times. Each time, immediately after listening the list, the subjects were required to repeat as many words as they could recall. Spectral coherence of the intracerebral EEG activity was computed in order to assess the temporal synchronization of the theta (about 3-8 Hz) rhythms among hippocampus, amygdala, and temporal-occipital neocortex. We found that theta coherence values between amygdala and hippocampus, and between hippocampus and occipital-temporal cortex, were higher in amplitude during successful than unsuccessful immediate recall. A control analysis showed that this was true also for a gamma band (40-45 Hz). Furthermore, these theta and gamma effects were not observed in an additional (control) subject with drug-resistant TLE and a wide lesion to hippocampus. In conclusion, a successful immediate recall to the RAVLT was associated to the enhancement of temporal synchronization of the theta (gamma) rhythms within a cerebral network including hippocampus, amygdala, and temporal-occipital neocortex.

MeSH Terms
Acoustic Stimulation Adult Amygdala/pathology,physiology Analysis of Variance Cerebral Cortex/pathology,physiology Cortical Synchronization Epilepsy, Temporal Lobe/pathology,physiopathology Female Hippocampus/pathology,physiology Humans Learning/physiology Magnetic Resonance Imaging Male Mental Recall/physiology Middle Aged Neuropsychological Tests Speech Theta Rhythm Time Factors
Authors & Affiliations
14 authors, click to expand affiliations / ORCID
Babiloni Claudio
Department of Biomedical Sciences, University of Foggia, Foggia, Italy. [email protected]
Vecchio Fabrizio
Mirabella Giovanni
Buttiglione Maura
Sebastiano Fabio
Picardi Angelo
Di Gennaro Giancarlo
Quarato Pier P
Grammaldo Liliana G
Buffo Paola
Esposito Vincenzo
Manfredi Mario
Cantore Giampaolo
Eusebi Fabrizio
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Article Info
Journal
Human brain mapping
Abbr.
Hum Brain Mapp
ISSN
1097-0193
DOI
10.1002/hbm.20648
Email
[email protected]
Published
2009-07-00
Pages
2077-89
Language
English
Region
United States
NLM ID
9419065
PMCID
PMC6871026
Subset
IM
External Links
PubMed source DOI: 10.1002/hbm.20648 PMC Full Text View journal details
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