Abstract
Using a positional cloning approach supported by comparative genomics, we have identified a previously unreported gene, EYS, at the RP25 locus on chromosome 6q12 commonly mutated in autosomal recessive retinitis pigmentosa. Spanning over 2 Mb, this is the largest eye-specific gene identified so far. EYS is independently disrupted in four other mammalian lineages, including that of rodents, but is well conserved from Drosophila to man and is likely to have a role in the modeling of retinal architecture.
MeSH Terms
Animals
Cell Line
Chromosomes, Human, Pair 6/genetics
Drosophila Proteins/chemistry
Drosophila melanogaster/chemistry
Eye Proteins/chemistry,genetics,metabolism
Gene Expression Profiling
Gene Expression Regulation
Genes, Recessive
Humans
Mutation/genetics
Protein Structure, Tertiary
Protein Transport
Retinitis Pigmentosa/genetics
Sequence Homology, Amino Acid
Chemicals
Drosophila Proteins
EYS protein, human
Eye Proteins
eys protein, Drosophila
Authors & Affiliations
17 authors, click to expand affiliations / ORCID
Abd El-Aziz Mai M
Department of Molecular Genetics, Institute of Ophthalmology, London EC1V 9EL, UK.
Barragan Isabel
O'Driscoll Ciara A
Goodstadt Leo
Prigmore Elena
Borrego Salud
Mena Marcela
Pieras Juan I
El-Ashry Mohamed F
Safieh Leen Abu
Shah Amna
Cheetham Michael E
Carter Nigel P
Chakarova Christina
Ponting Chris P
Bhattacharya Shomi S
Antinolo Guillermo
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