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PMID: 1884321 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Inflammation in the lung in cystic fibrosis. A vicious cycle that does more harm than good?

Clinical reviews in allergy ·Vol. 9 ·No. 1-2 ·1991-00-00 ·Pages 119-42

Berger M

Abstract

暂无摘要

MeSH Terms
Cystic Fibrosis/complications Humans Pneumonia/complications
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Berger M
Section of Immunologic and Infectious Diseases, Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, OH 44106.
References (77)
77 references, click to expand
  1. Alpha-1-antitrypsin augmentation therapy for alpha-1-antitrypsin deficiency.
    Am J Med. 1988 Jun 24;84(6A):52-62 PMID: 3289387
  2. Inactivation of human bronchial mucosal proteinase inhibitor by Pseudomonas aeruginosa elastase.
    Am Rev Respir Dis. 1982 Dec;126(6):1070-3 PMID: 6817677
  3. Induction of phagocytic inhibitory activity in cats with chronic Pseudomonas aeruginosa pulmonary infection.
    Infect Immun. 1982 Dec;38(3):1088-93 PMID: 6818144
  4. Immunohistopathologic localization of Pseudomonas aeruginosa in lungs from patients with cystic fibrosis. Implications for the pathogenesis of progressive lung deterioration.
    Am Rev Respir Dis. 1989 Dec;140(6):1650-61 PMID: 2513765
  5. Elastase from polymorphonuclear leucocytes: a regulatory enzyme in immune complex disease.
    Clin Exp Immunol. 1986 Jun;64(3):597-605 PMID: 2947759
  6. Proteins of the cystic fibrosis respiratory tract. Fragmented immunoglobulin G opsonic antibody causing defective opsonophagocytosis.
    J Clin Invest. 1984 Jul;74(1):236-48 PMID: 6429195
  7. Anti-neutrophil-elastase defenses of the lower respiratory tract in alpha 1-antitrypsin deficiency directly augmented with an aerosol of alpha 1-antitrypsin.
    Ann Intern Med. 1989 Aug 1;111(3):206-12 PMID: 2787611
  8. Role of fibronectin in the prevention of adherence of Pseudomonas aeruginosa to buccal cells.
    J Infect Dis. 1981 Jun;143(6):784-90 PMID: 6788858
  9. Pseudomonas aeruginosa alkaline protease degrades human gamma interferon and inhibits its bioactivity.
    Infect Immun. 1988 Nov;56(11):2925-32 PMID: 3139565
  10. Studies on the mechanism of T cell inhibition by the Pseudomonas aeruginosa phenazine pigment pyocyanine.
    J Immunol. 1987 May 15;138(10):3481-7 PMID: 2952718
  11. Immunoglobulin-G subclasses in cystic fibrosis. IgG2 response to Pseudomonas aeruginosa lipopolysaccharide.
    Am Rev Respir Dis. 1986 Mar;133(3):418-22 PMID: 3082264
  12. Prospective study of serum antibodies to Pseudomonas aeruginosa exoproteins in cystic fibrosis.
    J Clin Microbiol. 1987 Oct;25(10):1868-74 PMID: 3117842
  13. The lung in cystic fibrosis. A quantitative study including prevalence of pathologic findings among different age groups.
    Hum Pathol. 1976 Mar;7(2):195-204 PMID: 1262016
  14. Hypogammaglobulinemia in patients with cystic fibrosis.
    N Engl J Med. 1980 Jan 31;302(5):245-9 PMID: 7350477
  15. Stimulated mobilization of monocyte Mac-1 and p150,95 adhesion proteins from an intracellular vesicular compartment to the cell surface.
    J Clin Invest. 1987 Aug;80(2):535-44 PMID: 3038962
  16. Inflammatory and immune processes in the human lung in health and disease: evaluation by bronchoalveolar lavage.
    Am J Pathol. 1979 Oct;97(1):149-206 PMID: 495693
  17. Inactivation of human gamma interferon by Pseudomonas aeruginosa proteases: elastase augments the effects of alkaline protease despite the presence of alpha 2-macroglobulin.
    Infect Immun. 1989 Jun;57(6):1668-74 PMID: 2470675
  18. Sputum changes associated with therapy for endobronchial exacerbation in cystic fibrosis.
    J Pediatr. 1988 Apr;112(4):547-54 PMID: 3127569
  19. Inflammatory reaction and airway damage in cystic fibrosis.
    J Lab Clin Med. 1976 Sep;88(3):423-6 PMID: 8575
  20. Fibronectin-cleaving activity in bronchial secretions of patients with cystic fibrosis.
    J Infect Dis. 1988 Jul;158(1):89-100 PMID: 3292666
  21. Effects of pyocyanine, a blue pigment from Pseudomonas aeruginosa, on separate steps of T cell activation: interleukin 2 (IL 2) production, IL 2 receptor formation, proliferation and induction of cytolytic activity.
    Eur J Immunol. 1986 Apr;16(4):434-40 PMID: 2422042
  22. Receptors for complement of leukocytes.
    J Exp Med. 1968 Nov 1;128(5):991-1009 PMID: 4176227
  23. Lysosomal enzymes from polymorphonuclear leukocytes and proteinase inhibitors in patients with cystic fibrosis.
    Am Rev Respir Dis. 1986 Jul;134(1):49-56 PMID: 2425673
  24. Role of Pseudomonas aeruginosa mucoid exopolysaccharide in adherence to tracheal cells.
    Infect Immun. 1985 Jan;47(1):1-4 PMID: 3155514
  25. Antielastases of the human alveolar structures. Implications for the protease-antiprotease theory of emphysema.
    J Clin Invest. 1981 Oct;68(4):889-98 PMID: 6169740
  26. Production of mucoid microcolonies by Pseudomonas aeruginosa within infected lungs in cystic fibrosis.
    Infect Immun. 1980 May;28(2):546-56 PMID: 6772562
  27. Limited cleavage of human immunoglobulins by elastase of human neutrophil polymorphonuclear granulocytes. Possible modulator of immune complex disease.
    Lab Invest. 1978 Oct;39(4):313-21 PMID: 81354
  28. Release of inflammatory mediators from stimulated neutrophils.
    N Engl J Med. 1980 Jul 3;303(1):27-34 PMID: 6246431
  29. Alternate-day prednisone reduces morbidity and improves pulmonary function in cystic fibrosis.
    Lancet. 1985 Sep 28;2(8457):686-8 PMID: 2863676
  30. IgG proteolytic activity of Pseudomonas aeruginosa in cystic fibrosis.
    J Infect Dis. 1985 Apr;151(4):589-98 PMID: 3919115
  31. Association with phagocytic inhibition of anti-Pseudomonas aeruginosa immunoglobulin G antibody subclass levels in serum from patients with cystic fibrosis.
    J Clin Microbiol. 1986 Mar;23(3):513-6 PMID: 3082922
  32. Ibuprofen attenuates the inflammatory response to Pseudomonas aeruginosa in a rat model of chronic pulmonary infection. Implications for antiinflammatory therapy in cystic fibrosis.
    Am Rev Respir Dis. 1990 Jan;141(1):186-92 PMID: 2153353
  33. Sputum sol-phase proteins and elastase activity in patients with cystic fibrosis.
    Eur J Respir Dis. 1984 Feb;65(2):114-24 PMID: 6421611
  34. Oxygen-dependent microbial killing by phagocytes (first of two parts).
    N Engl J Med. 1978 Mar 23;298(12):659-68 PMID: 24176
  35. Protease and elastase of Pseudomonas aeruginosa: inactivation of human plasma alpha 1-proteinase inhibitor.
    Infect Immun. 1979 Apr;24(1):188-93 PMID: 110691
  36. Potential mediator of inflammation. Phagocyte-derived oxidants suppress the elastase-inhibitory capacity of alpha 1-proteinase inhibitor in vitro.
    J Clin Invest. 1980 Nov;66(5):987-95 PMID: 6253528
  37. A novel neutrophil-activating factor produced by human mononuclear phagocytes.
    J Exp Med. 1988 May 1;167(5):1547-59 PMID: 2835419
  38. Elastase in tissue injury.
    Annu Rev Med. 1985;36:207-16 PMID: 3888051
  39. Contribution of toxin A and elastase to virulence of Pseudomonas aeruginosa in chronic lung infections of rats.
    Infect Immun. 1982 Jun;36(3):1223-8 PMID: 6807846
  40. Pseudomonas aeruginosa infection in cystic fibrosis. Diagnostic and prognostic significance of Pseudomonas aeruginosa precipitins determined by means of crossed immunoelectrophoresis.
    Scand J Respir Dis. 1977 Apr;58(2):65-79 PMID: 404701
  41. Antibodies to proteases and exotoxin A of Pseudomonas aeruginosa in patients with cystic fibrosis: Demonstration by radioimmunoassay.
    J Infect Dis. 1978 Jul;138(1):49-8 PMID: 98596
  42. Interactions of Pseudomonas aeruginosa with immunoglobulins and complement in sputum.
    Infect Immun. 1976 Jul;14(1):114-7 PMID: 820637
  43. Adherence of streptococcus pyogenes, Escherichia coli, and Pseudomonas aeruginosa to fibronectin-coated and uncoated epithelial cells.
    Infect Immun. 1983 Sep;41(3):1261-8 PMID: 6411621
  44. Modulation of surface CD11/CD18 glycoproteins (Mo1, LFA-1, p150,95) by human mononuclear phagocytes.
    Clin Immunol Immunopathol. 1988 Feb;46(2):272-83 PMID: 3123109
  45. Immune complexes and humoral response to Pseudomonas aeruginosa in cystic fibrosis.
    Am Rev Respir Dis. 1980 Jan;121(1):23-9 PMID: 6766286
  46. In vitro inhibition of lymphocyte proliferation by Pseudomonas aeruginosa phenazine pigments.
    Infect Immun. 1983 Jul;41(1):321-30 PMID: 6408002
  47. Ultrastructure and function of alveolar macrophages from cystic fibrosis patients.
    Pediatr Res. 1980 May;14(5):715-21 PMID: 6770330
  48. Natural history of alpha-1-protease inhibitor deficiency.
    Am J Med. 1988 Jun 24;84(6A):3-12 PMID: 3289386
  49. Antiphagocytic Effect of Slime from a Mucoid Strain of Pseudomonas aeruginosa.
    Infect Immun. 1971 Jun;3(6):762-7 PMID: 16558051
  50. Complement activation in cystic fibrosis respiratory fluids: in vivo and in vitro generation of C5a and chemotactic activity.
    Pediatr Res. 1986 Dec;20(12):1258-68 PMID: 3540828
  51. The carbohydrate content of IgG from patients with cystic fibrosis.
    Pediatr Res. 1983 Dec;17(12):931-5 PMID: 6657324
  52. Pyocyanin and 1-hydroxyphenazine produced by Pseudomonas aeruginosa inhibit the beating of human respiratory cilia in vitro.
    J Clin Invest. 1987 Jan;79(1):221-9 PMID: 3098783
  53. Inhibition of human natural killer cell activity by Pseudomonas aeruginosa alkaline protease and elastase.
    Infect Immun. 1987 Apr;55(4):986-9 PMID: 3030937
  54. Leukotriene B4 production by the human alveolar macrophage: a potential mechanism for amplifying inflammation in the lung.
    Am Rev Respir Dis. 1984 Jan;129(1):106-11 PMID: 6322626
  55. Selective modulation of the CD4 molecular complex by Pseudomonas aeruginosa alkaline protease and elastase.
    Scand J Immunol. 1987 Jul;26(1):91-4 PMID: 3112933
  56. Inhibitory effect of cystic fibrosis serum on pseudomonas phagocytosis by rabbit and human alveolar macrophages.
    Pediatr Res. 1979 Sep;13(9):1085-8 PMID: 116188
  57. Biochemical and pathologic evidence for proteolytic destruction of lung connective tissue in cystic fibrosis.
    Am Rev Respir Dis. 1985 Sep;132(3):529-35 PMID: 3898942
  58. Altered antibody isotype in cystic fibrosis: possible role in opsonic deficiency.
    Pediatr Res. 1986 May;20(5):453-9 PMID: 3714355
  59. Lipid mediators in cystic fibrosis and chronic obstructive pulmonary disease.
    Am Rev Respir Dis. 1987 Sep;136(3):779-82 PMID: 2820284
  60. Functional differences between the 40 kDa and 50 to 70 kDa IgG Fc receptors on human neutrophils revealed by elastase treatment and antireceptor antibodies.
    J Immunol. 1988 Sep 15;141(6):2097-103 PMID: 2844894
  61. Immunologic investigations of mucoid strains of Pseudomonas aeruginosa: comparison of susceptibility to opsonic antibody in mucoid and nonmucoid strains.
    J Infect Dis. 1980 Feb;141(2):238-47 PMID: 6444976
  62. Microbial elastases. A comparative study.
    Proc Soc Exp Biol Med. 1962 Apr;109:923-5 PMID: 14469215
  63. Relationship of iron and extracellular virulence factors to Pseudomonas aeruginosa lung infections.
    J Med Microbiol. 1984 Aug;18(1):125-33 PMID: 6431109
  64. Immune complexes and complement abnormalities in patients with cystic fibrosis. Increased mortality associated with circulating immune complexes and decreased function of the alternative complement pathway.
    Am Rev Respir Dis. 1985 Oct;132(4):770-6 PMID: 3850731
  65. Evidence for the presence of components of the alternative (properdin) pathway of complement activation in respiratory secretions.
    J Immunol. 1976 Sep;117(3):900-3 PMID: 956659
  66. Cleavage of IgG by elastase-like protease (ELP) of human polymorphonuclear leukocytes (PMN): isolation and characterization of Fab and Fc fragments and low-molecular-weight peptides. Stimulation of granulocyte function by ELP-derived Fab and Fc fragments.
    Immunobiology. 1982 May;161(5):507-23 PMID: 7047381
  67. Complement receptor expression on neutrophils at an inflammatory site, the Pseudomonas-infected lung in cystic fibrosis.
    J Clin Invest. 1989 Oct;84(4):1302-13 PMID: 2507578
  68. Granulocyte neutral proteases and Pseudomonas elastase as possible causes of airway damage in patients with cystic fibrosis.
    J Infect Dis. 1984 Apr;149(4):523-31 PMID: 6427360
  69. Cystic fibrosis pseudomonas opsonins. Inhibitory nature in an in vitro phagocytic assay.
    J Clin Invest. 1981 Oct;68(4):899-914 PMID: 6793632
  70. Reticuloendothelial clearance in cystic fibrosis and other inflammatory lung diseases.
    N Engl J Med. 1988 Aug 11;319(6):338-43 PMID: 3393195
  71. Inhibition of human lymphocyte proliferation and cleavage of interleukin-2 by Pseudomonas aeruginosa proteases.
    Infect Immun. 1988 Jul;56(7):1673-7 PMID: 3133317
  72. Eicosanoids and lung inflammation.
    Am Rev Respir Dis. 1987 May;135(5):1176-85 PMID: 3107445
  73. Role of exotoxin and protease as possible virulence factors in experimental infections with Pseudomonas aeruginosa.
    Infect Immun. 1978 Mar;19(3):839-45 PMID: 417031
  74. Opsonic defect in patients with cystic fibrosis of the pancreas.
    Proc Natl Acad Sci U S A. 1971 Aug;68(8):1716-9 PMID: 5001942
  75. Levels of free granulocyte elastase in bronchial secretions from patients with cystic fibrosis: effect of antimicrobial treatment against Pseudomonas aeruginosa.
    J Infect Dis. 1986 May;153(5):902-9 PMID: 3486235
  76. Antiphagocytic effect of Pseudomonas aeruginosa exopolysaccharide.
    J Clin Pathol. 1980 Dec;33(12):1221-2 PMID: 6778898
  77. Analysis of proteins and respiratory cells obtained from human lungs by bronchial lavage.
    J Lab Clin Med. 1974 Oct;84(4):559-73 PMID: 4412011
Article Info
Journal
Clinical reviews in allergy
Abbr.
Clin Rev Allergy
ISSN
0731-8235
DOI
10.1007/978-1-4612-0475-6_8
Published
1991-00-00
Pages
119-42
Language
English
Region
United States
NLM ID
8308524
Subset
IM
Grants
NIAID NIH HHS · AI22687 · United States
NIDDK NIH HHS · DK 27651 · United States
External Links
PubMed source DOI: 10.1007/978-1-4612-0475-6_8
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