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PMID: 18850014 Published · ppublish English Journal Article

Response and toxicity of donor lymphocyte infusions following T-cell depleted non-myeloablative allogeneic hematopoietic SCT from 3-6/6 HLA matched donors.

Bone marrow transplantation ·Vol. 43 ·No. 4 ·2009-02-00 ·Pages 327-33

Rizzieri DA, Dev P, Long GD, Gasparetto C, Sullivan KM, Horwitz M, Chute J, Chao NJ

Abstract

We report the outcome of early donor lymphocyte infusions (DLIs) after T-cell depleted non-myeloablative transplantation using stem cells from HLA-matched or mismatched donors. Sixty-nine patients with high-risk hematologic malignancies received DLI following fludarabine, CY and alemtuzumab with infusion of stem cells from a matched sibling (52) or partially matched family member donor (17). Patients received the first infusion at a median of 50 days after transplant, and doses ranged from 1 x 10(4) CD3+ cells/kg to 3.27 x 10(8) CD3+ cells/kg, depending on clinical status and the physician's discretion. A median cell dose of 1 x 10(5) CD3+ cells/kg in the mismatched setting and 1 x 10(6) CD3+ cells/kg in the matched sibling setting appears safe with only 1 of 7 (14%) and 4 of 31 patients (13%), respectively, experiencing severe acute GVHD at these doses. Importantly, 38% of patients with persistent disease before DLI attained a remission after infusion. Nine of the 69 patients remain alive and disease-free 32-71 months after the first DLI. In conclusion, low doses of DLI can be safely provided soon after T-cell depleted non-myeloablative therapy and provide a chance of remission. However, long-term survival still remains poor, primarily because of relapse in these patients.

MeSH Terms
Acute Disease Adolescent Adult Aged Cohort Studies Graft Survival/immunology Graft vs Host Disease/etiology,immunology HLA Antigens/immunology Hematologic Neoplasms/immunology,therapy Hematopoietic Stem Cell Transplantation/adverse effects,methods Humans Lymphocyte Transfusion/adverse effects,methods Middle Aged Myeloablative Agonists/therapeutic use Prospective Studies Survivors T-Lymphocytes/cytology,immunology Tissue Donors Transplantation Conditioning/methods Treatment Outcome Young Adult
Chemicals
HLA Antigens Myeloablative Agonists
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Rizzieri D A
Division of Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. [email protected]
Dev P
Long G D
Gasparetto C
Sullivan K M
Horwitz Ml
Chute J
Chao N J
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Article Info
Journal
Bone marrow transplantation
Abbr.
Bone Marrow Transplant
ISSN
1476-5365
Published
2009-02-00
Epub
2008-00-13
Pages
327-33
Language
English
Region
England
NLM ID
8702459
PMCID
PMC3635807
Subset
IM
Grants
NCRR NIH HHS · K23 RR016063 · United States
NCI NIH HHS · P01 CA047741 · United States
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