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PMID: 188766 Published · ppublish English Journal Article

Cell-mediated immunity to Sendai virus infection in mice.

Infection and immunity ·Vol. 15 ·No. 1 ·1977-01-00 ·Pages 239-44

Anderson MJ, Bainbridge DR, Pattison JR, Heath RB

Abstract

The development of a cell-mediated immune response to Sendai virus infection in mice was examined by the use of a 51Cr release assay of cytotoxicity. A low level of "background cytotoxicity" to Sendai virus-infected L cells was found in the spleens of uninfected CBA mice. Spleen cells from Sendai-infected mice showed an elevated level of cytotoxicity against these target cells for a period of 5 weeks, commencing 4 days after infection of the mice. A more transient response was observed in the spleens of mice infected with a serologically distinct virus, the Kunz strain of influenza. This cross-reacting, cell-mediated immune response was intermediate between that observed in unsensitized and Sendai-sensitized spleen cells. The relevance of these cell-mediated immune responses to respiratory tract virus infections is discussed.

MeSH Terms
Animals Antibodies, Viral/biosynthesis Cell Line Cytopathogenic Effect, Viral Cytotoxicity Tests, Immunologic Immunity, Cellular Influenza A virus/immunology Mice Mice, Inbred CBA Orthomyxoviridae Infections/immunology Parainfluenza Virus 1, Human/immunology Paramyxoviridae Infections/immunology Spleen/immunology
Chemicals
Antibodies, Viral
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Anderson M J
Bainbridge D R
Pattison J R
Heath R B
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.15.1.239-244.1977
Published
1977-01-00
Pages
239-44
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC421354
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.15.1.239-244.1977 PMC Full Text View journal details
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