Inhibition of urease activity but not growth of Helicobacter pylori by acetohydroxamic acid.

Journal of clinical pathology ·Vol. 44 ·No. 8 ·1991-08-00 ·Pages 695-7

Goldie J, Veldhuyzen van Zanten SJ, Jalali S, Richardson H, Hunt RH

Abstract

The in vitro effects of acetohydroxamic acid (AHA), a potent urease inhibitor, were studied to determine the effect on the urease activity and growth of 38 strains of Helicobacter pylori. AHA in concentrations of 50-1000 mg/l had a noticeably reversible inhibitory effect on the urease activity of the organism but no effect on growth.

MeSH Terms

Dose-Response Relationship, Drug Helicobacter pylori/drug effects,enzymology,growth & development Hydroxamic Acids/pharmacology Urease/antagonists & inhibitors,metabolism

Chemicals

Hydroxamic Acids acetohydroxamic acid Urease

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Goldie J

Department of Laboratory Medicine, McMaster University Medical Centre, Hamilton, Ontario, Canada.

Veldhuyzen van Zanten S J

Jalali S

Richardson H

Hunt R H

References (10)

10 references, click to expand

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Campylobacter pyloridis, urease, hydrogen ion back diffusion, and gastric ulcers.
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Characterization of urease from Campylobacter pylori.
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A randomized double-blind study of acetohydroxamic acid in struvite nephrolithiasis.
N Engl J Med. 1984 Sep 20;311(12):760-4 PMID: 6472365
Inhibition of urease activity by hydroxamic acid derivatives of amino acids.
J Biochem. 1975 Apr;77(4):837-43 PMID: 238968
Interaction between acetohydroxamic acid and 12 antibiotics against 14 gram-negative pathogenic bacteria.
Antimicrob Agents Chemother. 1974 Feb;5(2):106-10 PMID: 4840425
Urease activity and antibiotic sensitivity of bacteria.
J Bacteriol. 1966 Feb;91(2):499-506 PMID: 5177405
Synthesis and metabolism of labeled acetohydroxamic acid, a urease inhibitor.
Proc Soc Exp Biol Med. 1971 Feb;136(2):592-6 PMID: 5544502
Urease inhibitors for hepatic coma. II. Comparative efficacy of four lower hydroxamate homologs in vitro and in vivo.
Proc Soc Exp Biol Med. 1970 Sep;134(4):1083-90 PMID: 5457735
Acetohydroxamate: bacterial urease inhibitor with therapeutic potential in hyperammonaemic states.
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Article Info

Journal

Journal of clinical pathology

Abbr.

J Clin Pathol

ISSN

0021-9746

DOI

10.1136/jcp.44.8.695

Published

1991-08-00

Pages

695-7

Language

English

Region

England

NLM ID

0376601

PMCID

PMC496771

Subset

Corrections

CommentIn

PMID: 1577984

External Links

PubMed source DOI: 10.1136/jcp.44.8.695 PMC Full Text View journal details

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Inhibition of urease activity but not growth of Helicobacter pylori by acetohydroxamic acid.

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