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PMID: 1895125 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Dopaminergic induced changes in cognitive and motor processing in Parkinson's disease: an electrophysiological investigation.

Journal of neurology, neurosurgery, and psychiatry ·Vol. 54 ·No. 7 ·1991-07-00 ·Pages 603-9

Prasher D, Findley L

Abstract

Event-related potentials and reaction time measures to auditory discrimination tasks of graded difficulty were used to separate cognitive from motor processing time in 27 patients with newly diagnosed, previously untreated Parkinson's disease and later on optimal levodopa treatment. Before treatment event-related potential P3 and task performance were normal but the reaction time was prolonged compared with age matched controls. After treatment P3 latency was significantly prolonged and the reaction time reduced suggesting a dopamine induced dissociation between cognitive and motor processing. In early Parkinson's disease cognitive processing time remains normal but the motor processing time is prolonged. Dopamine replacement is followed by significantly reduced motor processing time despite increased cognitive processing time. Motor processing may reflect the dopamine status of the putamen whereas dopaminergic over-stimulation of other regions may adversely affect cognitive processing in patients treated with levodopa.

MeSH Terms
Adult Aged Antiparkinson Agents Carbidopa/administration & dosage Cerebral Cortex/drug effects,physiopathology Cognition Disorders/diagnosis,drug therapy,physiopathology Dopamine/physiology Dose-Response Relationship, Drug Drug Combinations Electroencephalography/drug effects Evoked Potentials/drug effects,physiology Female Humans Levodopa/administration & dosage Male Middle Aged Neurologic Examination Parkinson Disease/diagnosis,drug therapy,physiopathology Psychomotor Performance/drug effects,physiology Reaction Time/drug effects,physiology Receptors, Dopamine/drug effects,physiology
Chemicals
Antiparkinson Agents Drug Combinations Receptors, Dopamine carbidopa, levodopa drug combination Levodopa Carbidopa Dopamine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Prasher D
Human Movement and Balance Unit, National Hospital, London, UK.
Findley L
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Article Info
Journal
Journal of neurology, neurosurgery, and psychiatry
Abbr.
J Neurol Neurosurg Psychiatry
ISSN
0022-3050
DOI
10.1136/jnnp.54.7.603
Published
1991-07-00
Pages
603-9
Language
English
Region
England
NLM ID
2985191R
PMCID
PMC1014430
Subset
IM
External Links
PubMed source DOI: 10.1136/jnnp.54.7.603 PMC Full Text View journal details
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