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PMID: 18953058 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Mechanisms and consequences of macrophage apoptosis in atherosclerosis.

Journal of lipid research ·Vol. 50 Suppl ·2009-04-00 ·Pages S382-7

Seimon T, Tabas I

Abstract

Macrophage apoptosis is an important feature of atherosclerotic plaque development. Research directed at understanding the functional consequences of macrophage death in atherosclerosis has revealed opposing roles for apoptosis in atherosclerotic plaque progression. In early lesions, macrophage apoptosis limits lesion cellularity and suppresses plaque progression. In advanced lesions, macrophages apoptosis promotes the development of the necrotic core, a key factor in rendering plaques vulnerable to disruption and in acute lumenal thrombosis. The first section of this review will examine the role of phagocytic clearance of apoptotic macrophages, a process known as efferocytosis, in the dichotomous roles of macrophage apoptosis in early vs. advanced lesions. The second section will focus on the molecular and cellular mechanisms that are thought to govern macrophage death during atherosclerosis. Of particular interest is the complex and coordinated role that the endoplasmic reticulum (ER) stress pathway and pattern recognition receptors (PRRs) may play in triggering macrophage apoptosis.

MeSH Terms
Animals Apoptosis Atherosclerosis/genetics,metabolism,pathology Endoplasmic Reticulum/metabolism Macrophages/cytology,metabolism Receptors, Pattern Recognition/metabolism
Chemicals
Receptors, Pattern Recognition
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Seimon Tracie
Department of Medicine, Columbia University, New York, NY 10032, USA.
Tabas Ira
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43 references, click to expand
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Article Info
Journal
Journal of lipid research
Abbr.
J Lipid Res
ISSN
0022-2275
DOI
10.1194/jlr.R800032-JLR200
Published
2009-04-00
Epub
2008-00-25
Pages
S382-7
Language
English
Region
United States
NLM ID
0376606
PMCID
PMC2674693
Subset
IM
Grants
NHLBI NIH HHS · P01 HL054591-130004 · United States
NHLBI NIH HHS · P01 HL054591 · United States
NHLBI NIH HHS · HL054591 · United States
NHLBI NIH HHS · HL087123 · United States
NHLBI NIH HHS · R01 HL075662 · United States
NHLBI NIH HHS · R01 HL075662-05 · United States
NHLBI NIH HHS · HL075662 · United States
NHLBI NIH HHS · P01 HL087123 · United States
NHLBI NIH HHS · P01 HL087123-01A10001 · United States
External Links
PubMed source DOI: 10.1194/jlr.R800032-JLR200 PMC Full Text View journal details
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