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PMID: 18980221 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Genome-wide association scan of attention deficit hyperactivity disorder.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics ·Vol. 147B ·No. 8 ·2008-12-05 ·Pages 1337-44

Neale BM, Lasky-Su J, Anney R, Franke B, Zhou K, Maller JB, Vasquez AA, Asherson P, Chen W, Banaschewski T, Buitelaar J, Ebstein R, Gill M, Miranda A, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Steinhausen HC, Sonuga-Barke E, Mulas F, Taylor E, Laird N, Lange C, Daly M, Faraone SV

Abstract

Results of behavioral genetic and molecular genetic studies have converged to suggest that genes substantially contribute to the development of attention deficit/hyperactivity disorder (ADHD), a common disorder with an onset in childhood. Yet, despite numerous linkage and candidate gene studies, strongly consistent and replicable association has eluded detection. To search for ADHD susceptibility genes, we genotyped approximately 600,000 SNPs in 958 ADHD affected family trios. After cleaning the data, we analyzed 438,784 SNPs in 2,803 individuals comprising 909 complete trios using ADHD diagnosis as phenotype. We present the initial TDT findings as well as considerations for cleaning family-based TDT data. None of the SNP association tests achieved genome-wide significance, indicating that larger samples may be required to identify risk loci for ADHD. We additionally identify a systemic bias in family-based association, and suggest that variable missing genotype rates may be the source of this bias.

MeSH Terms
Adolescent Algorithms Alleles Attention Deficit Disorder with Hyperactivity/diagnosis,genetics Case-Control Studies Child Child, Preschool Data Interpretation, Statistical Genome, Human Genome-Wide Association Study Homozygote Humans Linkage Disequilibrium Polymorphism, Single Nucleotide
Authors & Affiliations
26 authors, click to expand affiliations / ORCID
Neale Benjamin M
Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, UK.
Lasky-Su Jessica
Anney Richard
Franke Barbara
Zhou Kaixin
Maller Julian B
Vasquez Alejandro Arias
Asherson Philip
Chen Wai
Banaschewski Tobias
Buitelaar Jan
Ebstein Richard
Gill Michael
Miranda Ana
Oades Robert D
Roeyers Herbert
Rothenberger Aribert
Sergeant Joseph
Steinhausen Hans Christoph
Sonuga-Barke Edmund
Mulas Fernando
Taylor Eric
Laird Nan
Lange Christoph
Daly Mark
Faraone Stephen V
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Article Info
Journal
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
Abbr.
Am J Med Genet B Neuropsychiatr Genet
ISSN
1552-485X
DOI
10.1002/ajmg.b.30866
Published
2008-12-05
Pages
1337-44
Language
English
Region
United States
NLM ID
101235742
PMCID
PMC2831205
Subset
IM
Grants
NIMH NIH HHS · R01 MH062873 · United States
NIMH NIH HHS · R01 MH062873-05S1 · United States
NIMH NIH HHS · R01MH62873 · United States
External Links
PubMed source DOI: 10.1002/ajmg.b.30866 PMC Full Text View journal details
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