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PMID: 1900456 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides.

Cell ·Vol. 64 ·No. 5 ·1991-03-08 ·Pages 1037-46

Romeo C, Seed B

Abstract

We describe functional simplified T cell and Fc receptor chimeras that are capable of directing CD8+ cytotoxic T lymphocytes (CTLs) to specifically recognize and lyse cells expressing HIV envelope proteins. Target cells bearing HLA-DR molecules are not recognized by CTL armed with the chimeras. The variety of cell types in which the native receptors are active suggests multiple possibilities for antiviral intervention through genetic means.

MeSH Terms

Amino Acid Sequence Antigens, CD/immunology Antigens, Differentiation, T-Lymphocyte/immunology CD4 Antigens/genetics,immunology CD8 Antigens Calcium/metabolism Cell Line Chimera Cytotoxicity, Immunologic HIV/immunology HLA-DR Antigens/immunology Humans Molecular Sequence Data Mutagenesis, Site-Directed Receptors, Antigen, T-Cell/genetics,immunology Receptors, Fc/genetics,immunology Viral Envelope Proteins/immunology

Chemicals

Antigens, CD Antigens, Differentiation, T-Lymphocyte CD4 Antigens CD8 Antigens HLA-DR Antigens Receptors, Antigen, T-Cell Receptors, Fc Viral Envelope Proteins Calcium

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Romeo C

Department of Genetics, Harvard Medical School, Boston, Massachusetts.

Seed B

Article Info

Journal

Cell

Abbr.

Cell

ISSN

0092-8674

DOI

10.1016/0092-8674(91)90327-u

Published

1991-03-08

Pages

1037-46

Language

English

Region

United States

NLM ID

0413066

Subset

External Links

PubMed source DOI: 10.1016/0092-8674(91)90327-u View journal details

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Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides.

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