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PMID: 19007421 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

T cells in rheumatoid arthritis.

Arthritis research & therapy ·Vol. 10 Suppl 1 ·2008-00-00 ·Pages S1

Cope AP

Abstract

Over the past decade and a half, advances in our understanding of the pathogenesis of immune-mediated diseases such as rheumatoid arthritis (RA) have translated directly into benefit for patients. Much of this benefit has arisen through the introduction of targeted biological therapies. At the same time, technological advances have made it possible to define, at the cellular and molecular levels, the key pathways that influence the initiation and persistence of chronic inflammatory autoimmune reactions. As our understanding grows, it is likely that this knowledge will be translated into a second generation of biological therapies that are tailor-made for the patient. This review summarizes current perspectives on RA disease pathogenesis, with particular emphasis on what RA T cells look like, what they are likely to see, and how they contribute to persistence of the chronic inflammatory response.

MeSH Terms
Arthritis, Rheumatoid/immunology,therapy Humans T-Lymphocytes/immunology
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Cope Andrew P
The Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, Aspenlea Road, Hammersmith, London, W6 8LH, UK. [email protected]
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Article Info
Journal
Arthritis research & therapy
Abbr.
Arthritis Res Ther
ISSN
1478-6362
Published
2008-00-00
Epub
2008-00-15
Pages
S1
Language
English
Region
England
NLM ID
101154438
PMCID
PMC2582813
Subset
IM
Grants
Medical Research Council · United Kingdom
Wellcome Trust · United Kingdom
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