Interferon inhibits mouse leukaemia virus release: an electron microscope study.

The Journal of general virology ·Vol. 34 ·No. 2 ·1977-02-00 ·Pages 363-7

Chang EH, Mims SJ, Triche TJ, Friedman RM

Abstract

Scanning electron microscopy of AKR cells chronically infected with AKR mouse leukaemia virus revealed that the number of budding virions was greatly increased in interferon-treated cells. These results, together with previous biochemical findings, suggest that in this system, interferon inhibits a late stage of virus assembly or release.

MeSH Terms

AKR murine leukemia virus/drug effects,growth & development Animals Cell Line Cell Membrane/drug effects Interferons/pharmacology Leukemia Virus, Murine/growth & development Mice Microscopy, Electron, Scanning Virus Replication/drug effects

Chemicals

Interferons

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Chang E H

Mims S J

Triche T J

Friedman R M

Article Info

Journal

The Journal of general virology

Abbr.

J Gen Virol

ISSN

0022-1317

DOI

10.1099/0022-1317-34-2-363

Published

1977-02-00

Pages

363-7

Language

English

Region

England

NLM ID

0077340

Subset

External Links

PubMed source DOI: 10.1099/0022-1317-34-2-363 View journal details

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Interferon inhibits mouse leukaemia virus release: an electron microscope study.

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