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PMID: 19052556 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Toll-like receptors and cancer.

Nature reviews. Cancer ·Vol. 9 ·No. 1 ·2009-01-00 ·Pages 57-63

Rakoff-Nahoum S, Medzhitov R

Abstract

Toll-like receptors (TLRs) are a family of pattern recognition receptors that are best-known for their role in host defence from infection. Emerging evidence also suggests that TLRs have an important role in maintaining tissue homeostasis by regulating the inflammatory and tissue repair responses to injury. The development of cancer has been associated with microbial infection, injury, inflammation and tissue repair. Here we discuss how the function of TLRs may relate to these processes in the context of carcinogenesis.

MeSH Terms
Animals Cell Transformation, Neoplastic Homeostasis Humans Immunologic Surveillance Immunotherapy, Adoptive Infections/immunology,physiopathology Inflammation/immunology,physiopathology Ligands Mice Myeloid Differentiation Factor 88/deficiency,physiology Neoplasm Proteins/physiology Neoplasms/immunology,metabolism,therapy Regeneration/physiology Signal Transduction/physiology T-Lymphocyte Subsets/immunology Toll-Like Receptors/physiology Wound Healing/physiology
Chemicals
Ligands Myd88 protein, mouse Myeloid Differentiation Factor 88 Neoplasm Proteins Toll-Like Receptors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Rakoff-Nahoum Seth
Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA. [email protected]
Medzhitov Ruslan
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Article Info
Journal
Nature reviews. Cancer
Abbr.
Nat Rev Cancer
ISSN
1474-1768
DOI
10.1038/nrc2541
Email
[email protected]
Published
2009-01-00
Epub
2008-00-04
Pages
57-63
Language
English
Region
England
NLM ID
101124168
Subset
IM
Grants
Howard Hughes Medical Institute · United States
External Links
PubMed source DOI: 10.1038/nrc2541 View journal details
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