Home LiteratureArticle Details
PMID: 19064672 Published · ppublish English Comment Journal Article

Regulating polarity by directing traffic: Cdc42 prevents adherens junctions from crumblin' aPart.

The Journal of cell biology ·Vol. 183 ·No. 6 ·2008-12-15 ·Pages 971-4

Duncan MC, Peifer M

Abstract

The GTPase Cdc42 was among the original genes identified with roles in cell polarity, and interest in its cellular roles from yeast to humans remains high. Cdc42 is a well-known regulator of the actin cytoskeleton, but also plays important roles in vesicular trafficking. In this issue, Harris and Tepass (Harris, K.P, and U. Tepass. 2008. J. Cell. Biol. 183:1129-1143) provide new insights into how Cdc42 and Par proteins work together to modulate cell adhesion and polarity during embryonic morphogenesis by regulating the traffic of key cell junction proteins.

MeSH Terms
Adherens Junctions/enzymology Animals Cell Polarity Drosophila Proteins/metabolism Drosophila melanogaster/cytology,embryology,enzymology Endocytosis GTP-Binding Proteins/metabolism Models, Biological Multiprotein Complexes/metabolism Protein Transport
Chemicals
Cdc42 protein, Drosophila Drosophila Proteins Multiprotein Complexes GTP-Binding Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Duncan Mara C
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Peifer Mark
References (22)
22 references, click to expand
  1. The PAR proteins: fundamental players in animal cell polarization.
    Dev Cell. 2007 Nov;13(5):609-622 PMID: 17981131
  2. Multicopy suppression of the cdc24 budding defect in yeast by CDC42 and three newly identified genes including the ras-related gene RSR1.
    Proc Natl Acad Sci U S A. 1989 Dec;86(24):9976-80 PMID: 2690082
  3. Modulation of intracellular trafficking regulates cell intercalation in the Drosophila trachea.
    Nat Cell Biol. 2008 Aug;10(8):964-70 PMID: 18641639
  4. cdc42 regulates the exit of apical and basolateral proteins from the trans-Golgi network.
    EMBO J. 2001 May 1;20(9):2171-9 PMID: 11331583
  5. Making and breaking contacts: the cellular biology of cadherin regulation.
    Curr Opin Cell Biol. 2007 Oct;19(5):508-14 PMID: 17935963
  6. Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane.
    Dev Cell. 2005 Sep;9(3):365-76 PMID: 16224820
  7. Drosophila Cip4 and WASp define a branch of the Cdc42-Par6-aPKC pathway regulating E-cadherin endocytosis.
    Curr Biol. 2008 Nov 11;18(21):1639-48 PMID: 18976911
  8. The Drosophila homolog of the Exo84 exocyst subunit promotes apical epithelial identity.
    J Cell Sci. 2007 Sep 1;120(Pt 17):3099-110 PMID: 17698923
  9. The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye.
    Genes Dev. 1996 Nov 1;10(21):2759-68 PMID: 8946916
  10. Cdc42 controls secretory and endocytic transport to the basolateral plasma membrane of MDCK cells.
    Nat Cell Biol. 1999 May;1(1):8-13 PMID: 10559857
  11. Crumbs, a component of the apical membrane, is required for zonula adherens formation in primary epithelia of Drosophila.
    Dev Biol. 1996 Jul 10;177(1):217-25 PMID: 8660889
  12. Crosstalk between small GTPases and polarity proteins in cell polarization.
    Nat Rev Mol Cell Biol. 2008 Nov;9(11):846-59 PMID: 18946474
  13. Sequential roles of Cdc42, Par-6, aPKC, and Lgl in the establishment of epithelial polarity during Drosophila embryogenesis.
    Dev Cell. 2004 Jun;6(6):845-54 PMID: 15177032
  14. shotgun encodes Drosophila E-cadherin and is preferentially required during cell rearrangement in the neurectoderm and other morphogenetically active epithelia.
    Genes Dev. 1996 Mar 15;10(6):672-85 PMID: 8598295
  15. Genome-wide analysis identifies a general requirement for polarity proteins in endocytic traffic.
    Nat Cell Biol. 2007 Sep;9(9):1066-73 PMID: 17704769
  16. Cdc42--the centre of polarity.
    J Cell Sci. 2004 Mar 15;117(Pt 8):1291-300 PMID: 15020669
  17. Cdc42, Par6, and aPKC regulate Arp2/3-mediated endocytosis to control local adherens junction stability.
    Curr Biol. 2008 Nov 11;18(21):1631-8 PMID: 18976918
  18. Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion.
    Genes Dev. 1994 Aug 1;8(15):1787-802 PMID: 7958857
  19. Functional analysis of Cdc42 in actin filament assembly, epithelial morphogenesis, and cell signaling during Drosophila development.
    Dev Biol. 2000 May 1;221(1):181-94 PMID: 10772800
  20. Epithelial cell polarity and cell junctions in Drosophila.
    Annu Rev Genet. 2001;35:747-84 PMID: 11700298
  21. Cdc42 and Par proteins stabilize dynamic adherens junctions in the Drosophila neuroectoderm through regulation of apical endocytosis.
    J Cell Biol. 2008 Dec 15;183(6):1129-43 PMID: 19064670
  22. Rab11 maintains connections between germline stem cells and niche cells in the Drosophila ovary.
    Development. 2007 Oct;134(19):3413-8 PMID: 17715175
Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
1540-8140
DOI
10.1083/jcb.200811057
Published
2008-12-15
Epub
2008-00-08
Pages
971-4
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2600754
Subset
IM
Corrections
CommentOn
PMID: 19064670
External Links
PubMed source DOI: 10.1083/jcb.200811057 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2