Structural relationship between the vancomycin resistance protein VanH and 2-hydroxycarboxylic acid dehydrogenases.

Gene ·Vol. 103 ·No. 1 ·1991-07-15 ·Pages 133-4

Arthur M, Molinas C, Dutka-Malen S, Courvalin P

Abstract

Sequencing upstream from the vanA gene of enterococcal plasmid pIP816 that confers Vm resistance revealed the presence of an ORF which could code for a protein of 322 aa designated VanH. Extensive aa similarity was detected between VanH and 2-hydroxycarboxylic acid dehydrogenase. We discuss possible roles for VanH in the synthesis of a novel type of peptidoglycan precursors with lower affinity for Vm.

MeSH Terms

Alcohol Oxidoreductases/chemistry Amino Acid Sequence Bacterial Proteins/chemistry,genetics Base Sequence Carboxylic Acids/metabolism Drug Resistance, Microbial Enterococcus faecalis/drug effects,genetics Molecular Sequence Data Open Reading Frames/genetics Peptidoglycan/metabolism Plasmids/genetics Sequence Alignment Vancomycin/metabolism,pharmacology

Chemicals

Bacterial Proteins Carboxylic Acids Peptidoglycan VanH protein, Enterococcus faecium Vancomycin Alcohol Oxidoreductases

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Arthur M

Unité des Agents Antibactériens, Institut Pasteur, Paris, France.

Molinas C

Dutka-Malen S

Courvalin P

Article Info

Journal

Gene

Abbr.

Gene

ISSN

0378-1119

DOI

10.1016/0378-1119(91)90405-z

Published

1991-07-15

Pages

133-4

Language

English

Region

Netherlands

NLM ID

7706761

Subset

Databases

GENBANK

M64053, M64054, M64055, M64056, M64057, M64058, M64059, M64060, M64304, S53112

External Links

PubMed source DOI: 10.1016/0378-1119(91)90405-z View journal details

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Structural relationship between the vancomycin resistance protein VanH and 2-hydroxycarboxylic acid dehydrogenases.

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