Rules to 'prime' by.

Nature immunology ·Vol. 10 ·No. 1 ·2009-01-00 ·Pages 14-6

Thomas PG, Doherty PC

Abstract

A systems biology approach provides correlates of successful vaccination, which allows a new method for measuring early vaccine efficiency and suggests hypotheses for the mechanisms that underlie immunogenicity.

MeSH Terms

Algorithms Animals Clinical Trials as Topic Gene Expression Profiling/methods Humans Mice Proteome Systems Biology/methods Treatment Outcome Vaccination Yellow Fever/prevention & control Yellow Fever Vaccine/immunology,therapeutic use

Chemicals

Proteome Yellow Fever Vaccine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Thomas Paul G

Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

Doherty Peter C

References (5)

5 references, click to expand

LXR signaling couples sterol metabolism to proliferation in the acquired immune response.
Cell. 2008 Jul 11;134(1):97-111 PMID: 18614014
THE USE OF YELLOW FEVER VIRUS MODIFIED BY IN VITRO CULTIVATION FOR HUMAN IMMUNIZATION.
J Exp Med. 1937 May 31;65(6):787-800 PMID: 19870634
Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans.
Nat Immunol. 2009 Jan;10(1):116-125 PMID: 19029902
Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity.
J Exp Med. 2006 Feb 20;203(2):413-24 PMID: 16461338
Glucose availability regulates IFN-gamma production and p70S6 kinase activation in CD8+ effector T cells.
J Immunol. 2005 Apr 15;174(8):4670-7 PMID: 15814691

Article Info

Journal

Nature immunology

Abbr.

Nat Immunol

ISSN

1529-2916

DOI

10.1038/ni0109-14

Published

2009-01-00

Pages

14-6

Language

English

Region

United States

NLM ID

100941354

Subset

Corrections

CommentOn

PMID: 19029902

External Links

PubMed source DOI: 10.1038/ni0109-14 View journal details

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