CD4 and CD8 act as co-receptors during thymic selection of the T cell repertoire.

Seminars in immunology ·Vol. 3 ·No. 3 ·1991-05-00 ·Pages 167-75

Zúñiga-Pflücker JC, Jones LA, Chin LT, Kruisbeek AM

Abstract

The selection of T cell receptor specificities must logically not only involve the alpha beta-TCR but, also the CD4 and CD8 molecules, as antigen recognition by the alpha beta-TCR on mature T cells is facilitated by the CD4 and CD8 co-receptors. In this review, the studies that provided key advances in our understanding of the possible role of CD4 and CD8 in T cell development will be discussed.

MeSH Terms

Animals Antigens, CD/physiology Antigens, Differentiation, T-Lymphocyte/physiology CD4 Antigens/physiology CD8 Antigens Histocompatibility Antigens Class I/physiology Histocompatibility Antigens Class II/physiology Humans Mice Mice, Transgenic Receptors, Antigen, T-Cell/genetics,physiology T-Lymphocytes/immunology Thymus Gland/immunology

Chemicals

Antigens, CD Antigens, Differentiation, T-Lymphocyte CD4 Antigens CD8 Antigens Histocompatibility Antigens Class I Histocompatibility Antigens Class II Receptors, Antigen, T-Cell

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Zúñiga-Pflücker J C

Biological Response Modifiers Program, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

Jones L A

Chin L T

Kruisbeek A M

Article Info

Journal

Seminars in immunology

Abbr.

Semin Immunol

ISSN

1044-5323

Published

1991-05-00

Pages

167-75

Language

English

Region

England

NLM ID

9009458

Subset

External Links

PubMed source View journal details

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CD4 and CD8 act as co-receptors during thymic selection of the T cell repertoire.

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