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PMID: 19160396 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

A role for lipid droplets in inter-membrane lipid traffic.

Proteomics ·Vol. 9 ·No. 4 ·2009-02-00 ·Pages 914-21

Zehmer JK, Huang Y, Peng G, Pu J, Anderson RG, Liu P

Abstract

All cells have the capacity to accumulate neutral lipids and package them into lipid droplets. Recent proteomic analyses indicate that lipid droplets are not simple lipid storage depots, but rather complex organelles that have multiple cellular functions. One of these proposed functions is to distribute neutral lipids as well as phospholipids to various membrane-bound organelles within the cell. Here, we summarize the lipid droplet-associated membrane-trafficking proteins and review the evidence that lipid droplets interact with endoplasmic reticulum, endosomes, peroxisomes, and mitochondria. Based on this evidence, we present a model for how lipid droplets can distribute lipids to specific membrane compartments.

MeSH Terms
Animals Humans Lipids/physiology Membrane Proteins/metabolism Organelles/metabolism Phospholipids/metabolism Protein Transport/physiology Proteomics/methods Vesicular Transport Proteins/metabolism
Chemicals
Lipids Membrane Proteins Phospholipids Vesicular Transport Proteins
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Zehmer John K
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Huang Youguo
Peng Gong
Pu Jing
Anderson Richard G W
Liu Pingsheng
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Article Info
Journal
Proteomics
Abbr.
Proteomics
ISSN
1615-9861
DOI
10.1002/pmic.200800584
Published
2009-02-00
Pages
914-21
Language
English
Region
Germany
NLM ID
101092707
PMCID
PMC2676673
Subset
IM
Grants
NIGMS NIH HHS · P20 GM103476 · United States
NIGMS NIH HHS · GM 52016 · United States
NIGMS NIH HHS · R01 GM052016-14 · United States
NHLBI NIH HHS · HL 20948 · United States
NIGMS NIH HHS · R01 GM052016 · United States
NHLBI NIH HHS · P01 HL020948 · United States
NIGMS NIH HHS · GM 70117 · United States
NHLBI NIH HHS · P01 HL020948-260020 · United States
NIGMS NIH HHS · F32 GM070117 · United States
External Links
PubMed source DOI: 10.1002/pmic.200800584 PMC Full Text View journal details
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