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PMID: 19160495 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance.

Nature neuroscience ·Vol. 11 ·No. 9 ·2008-09-00 ·Pages 998-1000

Tong Q, Ye CP, Jones JE, Elmquist JK, Lowell BB

Abstract

The physiologic importance of GABAergic neurotransmission in hypothalamic neurocircuits is unknown. To examine the importance of GABA release from agouti-related protein (AgRP) neurons (which also release AgRP and neuropeptide Y), we generated mice with an AgRP neuron-specific deletion of vesicular GABA transporter. These mice are lean, resistant to obesity and have an attenuated hyperphagic response to ghrelin. Thus, GABA release from AgRP neurons is important in regulating energy balance.

MeSH Terms
2-Amino-5-phosphonovalerate/pharmacology 6-Cyano-7-nitroquinoxaline-2,3-dione/pharmacology Absorptiometry, Photon/methods Agouti-Related Protein/genetics,metabolism Analysis of Variance Animals Arcuate Nucleus of Hypothalamus/cytology Body Weight/physiology Eating/drug effects,physiology Energy Metabolism/genetics,physiology Excitatory Amino Acid Antagonists/pharmacology Female Ghrelin/pharmacology Green Fluorescent Proteins/genetics In Vitro Techniques Inhibitory Postsynaptic Potentials/drug effects,genetics Male Mice Mice, Transgenic Neurons/drug effects,metabolism Oxygen Consumption/genetics,physiology Patch-Clamp Techniques Sex Factors Synapses/metabolism Vesicular Inhibitory Amino Acid Transport Proteins/genetics,metabolism gamma-Aminobutyric Acid/metabolism
Chemicals
Agouti-Related Protein Excitatory Amino Acid Antagonists Ghrelin Vesicular Inhibitory Amino Acid Transport Proteins Viaat protein, mouse Green Fluorescent Proteins gamma-Aminobutyric Acid 6-Cyano-7-nitroquinoxaline-2,3-dione 2-Amino-5-phosphonovalerate
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Tong Qingchun
Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Ave., Boston, Massachusetts 02215, USA.
Ye Chian-Ping
Jones Juli E
Elmquist Joel K
Lowell Bradford B
References (15)
15 references, click to expand
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Article Info
Journal
Nature neuroscience
Abbr.
Nat Neurosci
ISSN
1546-1726
DOI
10.1038/nn.2167
Published
2008-09-00
Pages
998-1000
Language
English
Region
United States
NLM ID
9809671
PMCID
PMC2662585
Subset
IM
Grants
NIDDK NIH HHS · P01 DK056116-050003 · United States
NIDDK NIH HHS · P01 DK056116-090003 · United States
NIDDK NIH HHS · R01 DK053301-09 · United States
NIDDK NIH HHS · P30 DK046200-119004 · United States
NIDDK NIH HHS · R01 DK071051 · United States
NIDDK NIH HHS · R01 DK071051-05 · United States
NIDDK NIH HHS · P30 DK046200 · United States
NIDDK NIH HHS · R01 DK071320-04 · United States
NIDDK NIH HHS · R01 DK53301 · United States
NIDDK NIH HHS · R01 DK056690 · United States
NIDDK NIH HHS · R01 DK071320 · United States
NIDDK NIH HHS · P30 DK057521-09 · United States
NIDDK NIH HHS · P30 DK046200-156613 · United States
NIDDK NIH HHS · R01 DK053301 · United States
NIDDK NIH HHS · P01 DK56116 · United States
NIDDK NIH HHS · P30 DK046200-10 · United States
NIDDK NIH HHS · P01 DK056116 · United States
NIDDK NIH HHS · P30 DK057521 · United States
External Links
PubMed source DOI: 10.1038/nn.2167 PMC Full Text View journal details
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