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PMID: 19166320 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Central nervous system: cholesterol turnover, brain development and neurodegeneration.

Biological chemistry ·Vol. 390 ·No. 4 ·2009-04-00 ·Pages 287-93

Dietschy JM

Abstract

The average amount of cholesterol in the whole animal equals approximately 2100 mg/kg body weight, and 15% and 23% of this sterol in the mouse and human, respectively, is found in the central nervous system. There is no detectable uptake across the blood-brain barrier of cholesterol carried in lipoproteins in the plasma, even in the newborn. However, high rates of de novo cholesterol synthesis in the glia and neurons provide the sterol necessary for early brain development. Once a stable brain size is achieved in the adult, cholesterol synthesis continues, albeit at a much lower rate, and this synthesis is just balanced by the excretion of an equal amount of sterol, either as 24(S)-hydroxycholesterol or, presumably, as cholesterol itself.

MeSH Terms
Animals Central Nervous System/drug effects,growth & development,pathology Cholesterol/metabolism,pharmacology Humans Nerve Degeneration
Chemicals
Cholesterol
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Dietschy John M
Department of Internal Medicine, University of TexasSouthwestern Medical School, Dallas, TX 75390-9151,USA. [email protected]
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Article Info
Journal
Biological chemistry
Abbr.
Biol Chem
ISSN
1431-6730
DOI
10.1515/BC.2009.035
Email
[email protected]
Published
2009-04-00
Pages
287-93
Language
English
Region
Germany
NLM ID
9700112
PMCID
PMC3066069
Subset
IM
Grants
NHLBI NIH HHS · R01 HL009610 · United States
NHLBI NIH HHS · R01 HL009610-45 · United States
External Links
PubMed source DOI: 10.1515/BC.2009.035 PMC Full Text View journal details
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