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PMID: 1916813 Published · ppublish English Journal Article

A pseudogene on the X chromosome for the human trifunctional enzyme MTHFD (methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase).

Genomics ·Vol. 10 ·No. 4 ·1991-08-00 ·Pages 1073-4

Italiano C, John SW, Hum DW, MacKenzie RE, Rozen R

Abstract

The human trifunctional folate-dependent protein MTHFD has been mapped to chromosome 14q24 and to the X chromosome was identified by screening an X-chromosome-specific library. Amplification by the polymerase chain reaction (PCR) and sequencing of PCR products indicate that the sequence is an intronless pseudogene.

MeSH Terms
Aminohydrolases/genetics Base Sequence Chromosome Banding Chromosome Mapping Chromosomes, Human, Pair 14 DNA/genetics,isolation & purification Formate-Tetrahydrofolate Ligase/genetics Gene Library Humans Methylenetetrahydrofolate Dehydrogenase (NADP)/genetics Molecular Sequence Data Multienzyme Complexes/genetics Polymerase Chain Reaction/methods Pseudogenes X Chromosome
Chemicals
Multienzyme Complexes methylene tetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase formyl-methenyl-methylenetetrahydrofolate synthetase DNA Methylenetetrahydrofolate Dehydrogenase (NADP) Aminohydrolases Formate-Tetrahydrofolate Ligase
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Italiano C
Department of Pediatrics, McGill University, Montreal Children's Hospital Research Institute, Montreal, Quebec, Canada.
John S W
Hum D W
MacKenzie R E
Rozen R
Article Info
Journal
Genomics
Abbr.
Genomics
ISSN
0888-7543
DOI
10.1016/0888-7543(91)90201-o
Published
1991-08-00
Pages
1073-4
Language
English
Region
United States
NLM ID
8800135
Subset
IM
Databases
GENBANK
M64102, M64103, M64104, M64105, M75124, M75125, M75127, M75129, M75130, S57009
External Links
PubMed source DOI: 10.1016/0888-7543(91)90201-o View journal details
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