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PMID: 19190071 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Leptin at 14 y of age: an ongoing story.

The American journal of clinical nutrition ·Vol. 89 ·No. 3 ·2009-03-00 ·Pages 973S-979S

Friedman JM

Abstract

The cloning of the ob gene and its gene product leptin has led to the elucidation of a robust physiologic system that maintains constancy of fat stores. Leptin is a peptide hormone secreted by adipose tissue and regulates adipose tissue mass and energy balance. Recessive mutations in the leptin gene are associated with massive obesity in mice and in some humans, which establishes a genetic basis for obesity. Leptin circulates in blood and acts on the brain to regulate food intake and energy expenditure. When fat mass decreases, plasma leptin concentrations decrease, which stimulates appetite and suppresses energy expenditure until fat mass is restored. When fat mass increases, leptin concentrations increase, which suppresses appetite until weight is lost. This system maintains homeostatic control of adipose tissue mass.

MeSH Terms
Adipose Tissue/metabolism Animals Body Weight/physiology Cloning, Molecular Humans Leptin/genetics,metabolism,physiology
Chemicals
Leptin
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Friedman Jeffrey M
Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, Campus Box 305, New York, NY 10065, USA. [email protected]
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Article Info
Journal
The American journal of clinical nutrition
Abbr.
Am J Clin Nutr
ISSN
1938-3207
DOI
10.3945/ajcn.2008.26788B
Email
[email protected]
Published
2009-03-00
Epub
2009-00-03
Pages
973S-979S
Language
English
Region
United States
NLM ID
0376027
PMCID
PMC2667654
Subset
IM
Grants
Howard Hughes Medical Institute · United States
External Links
PubMed source DOI: 10.3945/ajcn.2008.26788B PMC Full Text View journal details
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