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PMID: 19203221 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Cardiac repair with adult bone marrow-derived cells: the clinical evidence.

Antioxidants & redox signaling ·Vol. 11 ·No. 8 ·2009-08-00 ·Pages 1865-82

Dawn B, Abdel-Latif A, Sanganalmath SK, Flaherty MP, Zuba-Surma EK

Abstract

On the basis of strong evidence from animal studies, numerous clinical trials of cardiac repair with adult bone marrow-derived cells (BMC) have been completed. These relatively smaller studies employed different BMC types with highly variable numbers, routes, and timings of transplantation, and included patients with acute myocardial infarction (MI), chronic ischemic heart disease (IHD), as well as ischemic cardiomyopathy. Although the outcomes have been predictably disparate, analysis of pooled data indicates that BMC therapy in patients with acute MI and chronic IHD results in modest improvements in left ventricular function and infarct scar size without any increase in untoward effects. However, the precise mechanisms underlying these benefits remain to be ascertained, and the specific advantages of one BMC type over another remain to be determined. The long-term benefit and safety issues with different BMC types are currently being evaluated critically in larger randomized controlled trials with a view to applying this novel therapeutic strategy to broader patient populations. The purpose of this review is to summarize the available clinical evidence regarding the efficacy and safety of therapeutic cardiac repair with different types of adult BMCs, and to discuss the key variables that need optimization to further enhance the benefits of BMC therapy.

MeSH Terms
Adult Animals Bone Marrow Cells/cytology Cell Transplantation Controlled Clinical Trials as Topic Heart Diseases/therapy Humans Regeneration
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Dawn Buddhadeb
Division of Cardiovascular Medicine and the Institute of Molecular Cardiology, University of Louisville, Louisville, Kentucky 40292, USA. [email protected]
Abdel-Latif Ahmed
Sanganalmath Santosh K
Flaherty Michael P
Zuba-Surma Ewa K
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Article Info
Journal
Antioxidants & redox signaling
Abbr.
Antioxid Redox Signal
ISSN
1557-7716
DOI
10.1089/ars.2009.2462
Email
[email protected]
Published
2009-08-00
Pages
1865-82
Language
English
Region
United States
NLM ID
100888899
PMCID
PMC2848520
Subset
IM
Grants
NHLBI NIH HHS · HL-89939 · United States
NHLBI NIH HHS · R01 HL-72410 · United States
NHLBI NIH HHS · R21 HL-89737 · United States
External Links
PubMed source DOI: 10.1089/ars.2009.2462 PMC Full Text View journal details
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