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PMID: 19210179 Published · ppublish English Journal Article Multicenter Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Genetic influences on type 2 diabetes and metabolic syndrome related quantitative traits in Mauritius.

Twin research and human genetics : the official journal of the International Society for Twin Studies ·Vol. 12 ·No. 1 ·2009-02-00 ·Pages 44-52

Jowett JB, Diego VP, Kotea N, Kowlessur S, Chitson P, Dyer TD, Zimmet P, Blangero J

Abstract

Epidemiological studies report a high prevalence of type 2 diabetes and metabolic syndrome in the island nation of Mauritius. The Mauritius Family Study was initiated to examine heritable factors that contribute to these high rates of prevalence and consists of 400 individuals in 24 large extended multigenerational pedigrees. Anthropometric and biochemical measurements relating to the metabolic syndrome were undertaken in addition to family and lifestyle based information for each individual. Variance components methods were used to determine the heritability of the type 2 diabetes and metabolic syndrome related quantitative traits. The cohort was made up of 218 females (55%) and 182 males with 22% diagnosed with type 2 diabetes and a further 30% having impaired glucose tolerance or impaired fasting glucose. Notably BMI was not significantly increased in those with type 2 diabetes (P= .12), however a significant increase in waist circumference was observed in these groups (P= .02). The heritable proportion of trait variance was substantial and greater than values previously published for hip circumference, LDL and total cholesterol, diastolic and systolic blood pressure and serum creatinine. Height, weight and BMI heritabilities were all in the upper range of those previously reported. The phenotypic characteristics of the Mauritius family cohort are similar to those previously reported in the Mauritian population with a high observed prevalence rate of type 2 diabetes. A high heritability for key type 2 diabetes and metabolic syndrome related phenotypes (range 0.23 to 0.68), suggest the cohort will have utility in identifying genes that influence these quantitative traits.

MeSH Terms
Blood Pressure/genetics Cholesterol/blood Cohort Studies Creatinine/blood Diabetes Mellitus, Type 2/blood,epidemiology,genetics Female Glucose Intolerance/blood,epidemiology,genetics Humans Lipoproteins, LDL/blood Male Mauritius/epidemiology Metabolic Syndrome/blood,epidemiology,genetics Prevalence Quantitative Trait, Heritable
Chemicals
Lipoproteins, LDL Cholesterol Creatinine
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Jowett Jeremy B
Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia. [email protected]
Diego Vincent P
Kotea Navaratnam
Kowlessur Sudhir
Chitson Pierrot
Dyer Thomas D
Zimmet Paul
Blangero John
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Article Info
Journal
Twin research and human genetics : the official journal of the International Society for Twin Studies
Abbr.
Twin Res Hum Genet
ISSN
1832-4274
DOI
10.1375/twin.12.1.44
Email
[email protected]
Published
2009-02-00
Pages
44-52
Language
English
Region
England
NLM ID
101244624
PMCID
PMC2923577
Subset
IM
Grants
NIMH NIH HHS · R01 MH059490 · United States
NIMH NIH HHS · R37 MH059490 · United States
NIMH NIH HHS · R37 MH059490-11 · United States
NIMH NIH HHS · MH059490 · United States
External Links
PubMed source DOI: 10.1375/twin.12.1.44 PMC Full Text View journal details
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