Molecular cloning of cell adhesion molecule L1 from human nervous tissue: a comparison of the primary sequences of L1 molecules of different origin.

Biochimica et biophysica acta ·Vol. 1090 ·No. 2 ·1991-10-08 ·Pages 238-40

Kobayashi M, Miura M, Asou H, Uyemura K

Abstract

Complementary DNA for the human neural cell adhesion molecule L1 was cloned and sequenced: the deduced amino acid sequence consists of 1257 amino acid residues containing six repeats of the immunoglobulin C2 domain and five repeats of the fibronectin type III domain. The intracellular domain of human L1 is highly conserved as compared to mouse, but not identical to L1 cloned from human melanoma cells, suggesting the existence of alternative forms in the same species.

MeSH Terms

Amino Acid Sequence Animals Base Sequence Brain Chemistry Cell Adhesion Molecules, Neuronal/biosynthesis,genetics Cloning, Molecular Fibronectins/genetics Humans Leukocyte L1 Antigen Complex Mice Molecular Sequence Data Recombinant Proteins/biosynthesis,genetics Sequence Alignment Tumor Cells, Cultured/metabolism

Chemicals

Cell Adhesion Molecules, Neuronal Fibronectins Leukocyte L1 Antigen Complex Recombinant Proteins

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Kobayashi M

Department of Physiology, Keio University School of Medicine, Tokyo, Japan.

Miura M

Asou H

Uyemura K

Article Info

Journal

Biochimica et biophysica acta

Abbr.

Biochim Biophys Acta

ISSN

0006-3002

DOI

10.1016/0167-4781(91)90108-x

Published

1991-10-08

Pages

238-40

Language

English

Region

Netherlands

NLM ID

0217513

Subset

Databases

GENBANK

D00761, D00762, D00763, M75974, M75975, S61186, X57933, X57934, X57935, X59847

External Links

PubMed source DOI: 10.1016/0167-4781(91)90108-x

Analysis Services

Molecular cloning of cell adhesion molecule L1 from human nervous tissue: a comparison of the primary sequences of L1 molecules of different origin.

Contact

WeChat Official Account