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PMID: 1933032 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Autocrine and paracrine growth factors in tumor growth: a mathematical model.

Bulletin of mathematical biology ·Vol. 53 ·No. 4 ·1991-00-00 ·Pages 639-56

Michelson S, Leith J

Abstract

A mathematical model of tumor growth including autocrine and paracrine control has been developed. The model starts with the logistic equation of Verhulst: dV/dt = rV (1-V/K). Autocrine controls are described as modifiers of the Malthusian growth rate (r), while paracrine controls modify the carrying capacity (K) of the system. The control mechanisms are expressed in terms of "candidate" functions, which are based upon the dynamic distribution of TGF-alpha TGF-beta in the local tumor environment. Three paradigms of tissue growth have been modeled: normal tissue wound repair, unrestricted, unperturbed tumor growth, and tumor growth in a (radiation) damaged environment (the Tumor Bed Effect, TBE). These scenarios were used to test the dynamics of the system against known phenomena. Computer simulations are presented for each case. The mode is being extended to include the description of heterogeneous tumors, within which subpopulations can express differential degrees of growth activity. Heterogeneous tumor models, with and without emergent subpopulations, and models of terminal differentiation are also discussed.

MeSH Terms
Animals Computer Simulation Models, Biological Models, Theoretical Neoplasms, Experimental/pathology,physiopathology Transforming Growth Factors/physiology
Chemicals
Transforming Growth Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Michelson S
Institute for Research Data Management, Syntex Corporation, Palo Alto, CA 94303.
Leith J
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Article Info
Journal
Bulletin of mathematical biology
Abbr.
Bull Math Biol
ISSN
0092-8240
Published
1991-00-00
Pages
639-56
Language
English
Region
United States
NLM ID
0401404
Subset
IM
Grants
NCI NIH HHS · CA50350 · United States
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