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PMID: 19333451 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The importance of brain banks for molecular neuropathological research: The New South Wales Tissue Resource Centre experience.

International journal of molecular sciences ·Vol. 10 ·No. 1 ·2009-01-00 ·Pages 366-84

Dedova I, Harding A, Sheedy D, Garrick T, Sundqvist N, Hunt C, Gillies J, Harper CG

Abstract

New developments in molecular neuropathology have evoked increased demands for postmortem human brain tissue. The New South Wales Tissue Resource Centre (TRC) at The University of Sydney has grown from a small tissue collection into one of the leading international brain banking facilities, which operates with best practice and quality control protocols. The focus of this tissue collection is on schizophrenia and allied disorders, alcohol use disorders and controls. This review highlights changes in TRC operational procedures dictated by modern neuroscience, and provides examples of applications of modern molecular techniques to study the neuropathogenesis of many different brain disorders.

Keywords
Human alcohol brain bank clinical characterization genome molecular neuropathology postmortem proteome receptor binding schizophrenia
MeSH Terms
Biological Specimen Banks/organization & administration,standards Brain/pathology Humans Neurology/methods,organization & administration Pathology, Clinical/methods,organization & administration Wales
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Dedova Irina
Schizophrenia Research Institute, Sydney, NSW, Australia. [email protected] <[email protected]>
Harding Antony
Sheedy Donna
Garrick Therese
Sundqvist Nina
Hunt Clare
Gillies Juliette
Harper Clive G
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Article Info
Journal
International journal of molecular sciences
Abbr.
Int J Mol Sci
ISSN
1422-0067
DOI
10.3390/ijms10010366
Email
[email protected]
Published
2009-01-00
Epub
2009-00-23
Pages
366-84
Language
English
Region
Switzerland
NLM ID
101092791
PMCID
PMC2662458
Subset
IM
Grants
NIAAA NIH HHS · R24 AA012725 · United States
NIAAA NIH HHS · R28 AA012725 · United States
External Links
PubMed source DOI: 10.3390/ijms10010366 PMC Full Text View journal details
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