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PMID: 19337847 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Influence of genetic background on tumor karyotypes: evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma.

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology ·Vol. 17 ·No. 3 ·2009-00-00 ·Pages 365-377

Thomas R, Wang HJ, Tsai PC, Langford CF, Fosmire SP, Jubala CM, Getzy DM, Cutter GR, Modiano JF, Breen M

Abstract

Recurrent chromosomal aberrations in solid tumors can reveal the genetic pathways involved in the evolution of a malignancy and in some cases predict biological behavior. However, the role of individual genetic backgrounds in shaping karyotypes of sporadic tumors is unknown. The genetic structure of purebred dog breeds, coupled with their susceptibility to spontaneous cancers, provides a robust model with which to address this question. We tested the hypothesis that there is an association between breed and the distribution of genomic copy number imbalances in naturally occurring canine tumors through assessment of a cohort of Golden Retrievers and Rottweilers diagnosed with spontaneous appendicular osteosarcoma. Our findings reveal significant correlations between breed and tumor karyotypes that are independent of gender, age at diagnosis, and histological classification. These data indicate for the first time that individual genetic backgrounds, as defined by breed in dogs, influence tumor karyotypes in a cancer with extensive genomic instability.

MeSH Terms
Animals Chromosome Aberrations/veterinary Comparative Genomic Hybridization Dog Diseases/genetics Dogs Genetic Predisposition to Disease/genetics Karyotyping/veterinary Osteosarcoma/genetics,veterinary Species Specificity
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Thomas Rachael
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA. | Center for Comparative Medicine and Translational Research, North Carolina State University, Raleigh, NC 27606, USA.
Wang Huixia J
Department of Statistics, College of Agriculture and Life Sciences, North Carolina State University, Raleigh, NC 27695, USA.
Tsai Pei-Chien
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA.
Langford Cordelia F
Microarray Facility, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Fosmire Susan P
Integrated Department of Immunology, University of Colorado, Denver, CO 80214, USA.
Jubala Cristan M
Integrated Department of Immunology, University of Colorado, Denver, CO 80214, USA.
Getzy David M
Idexx Veterinary Services, Broomfield, CO 80020, USA.
Cutter Gary R
Department of Biostatistics, University of Alabama Birmingham, Birmingham, AL 35294, USA.
Modiano Jaime F
Integrated Department of Immunology, University of Colorado, Denver, CO 80214, USA. | University of Colorado Cancer Center, Aurora, CO 80045, USA. | Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA. | Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.
Breen Matthew
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA. | Center for Comparative Medicine and Translational Research, North Carolina State University, Raleigh, NC 27606, USA.
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Article Info
Journal
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology
Abbr.
Chromosome Res
ISSN
1573-6849
DOI
10.1007/s10577-009-9028-z
Published
2009-00-00
Epub
2009-00-01
Pages
365-377
Language
English
Region
Netherlands
NLM ID
9313452
PMCID
PMC3758998
Subset
IM
Grants
Wellcome Trust · 079643 · United Kingdom
Wellcome Trust · 098051 · United Kingdom
External Links
PubMed source DOI: 10.1007/s10577-009-9028-z PMC Full Text View journal details
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