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PMID: 19350630 Published · ppublish English Comparative Study Journal Article Randomized Controlled Trial Research Support, N.I.H., Extramural

Family history of cancer and nonmalignant lung diseases as risk factors for lung cancer.

International journal of cancer ·Vol. 125 ·No. 1 ·2009-07-01 ·Pages 146-52

Gao Y, Goldstein AM, Consonni D, Pesatori AC, Wacholder S, Tucker MA, Caporaso NE, Goldin L, Landi MT

Abstract

Family history (FH) of lung cancer is an established risk factor for lung cancer, but the modifying effect of smoking in relatives has been rarely examined. Also, the role of FH of nonmalignant lung diseases on lung cancer risk is not well known. We examined the role of FH of cancer and nonmalignant lung diseases in lung cancer risk overall, and by personal smoking, FH of smoking and histology in 1,946 cases and 2,116 population-based controls within the Environment And Genetics in Lung cancer Etiology (EAGLE) study. Odds ratios (ORs) and 95% CI from logistic regression were calculated adjusting for age, gender, residence, education and cigarette smoking. FH of lung cancer in any family member was associated with increased lung cancer risk (OR = 1.57, 95% CI = 1.25-1.98). The odds associated with fathers', mothers' and siblings' history of lung cancer were 1.41, 2.14 and 1.53, respectively. The associations were generally stronger in never smokers, younger subjects and for the adenocarcinoma and squamous cell carcinoma subtypes. FH of chronic bronchitis and pneumonia was associated with increased (OR = 1.49, 95% CI = 1.23-1.80) and decreased (OR = 0.73, 95% CI = 0.61-0.87) lung cancer risk, respectively. FH of lung cancer and nonmalignant lung diseases affected lung cancer risk independently, and did not appear to be modified by FH of smoking.

MeSH Terms
Adenocarcinoma/epidemiology,genetics Adult Aged Bronchitis, Chronic/epidemiology Carcinoma, Squamous Cell/epidemiology,genetics Case-Control Studies Family Health Female Genetic Predisposition to Disease Humans Italy/epidemiology Lung Diseases/epidemiology Lung Neoplasms/epidemiology,genetics Male Middle Aged Pneumonia/epidemiology Pulmonary Emphysema/epidemiology Risk Factors Tuberculosis/epidemiology
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Gao Ying
Division of Cancer Epidemiology and Genetics, Genetic Epidemiology Branch, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892-7236, USA.
Goldstein Alisa M
Consonni Dario
Pesatori Angela C
Wacholder Sholom
Tucker Margaret A
Caporaso Neil E
Goldin Lynn
Landi Maria Teresa
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Article Info
Journal
International journal of cancer
Abbr.
Int J Cancer
ISSN
1097-0215
DOI
10.1002/ijc.24283
Published
2009-07-01
Pages
146-52
Language
English
Region
United States
NLM ID
0042124
PMCID
PMC2865851
Subset
IM
Grants
Intramural NIH HHS · Z01 CP005804-13 · United States
External Links
PubMed source DOI: 10.1002/ijc.24283 PMC Full Text View journal details
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