Effect of kirromycin on elongation factor Tu. Location of the catalytic center for ribosome-elongation-factor-Tu GTPase activity on the elongation factor.

Anti-Bacterial Agents/pharmacology Escherichia coli/drug effects,metabolism GTP Phosphohydrolase-Linked Elongation Factors/metabolism Guanosine Triphosphate/pharmacology Kinetics Peptide Chain Elongation, Translational/drug effects Peptide Elongation Factors Phenylalanine Phosphoric Monoester Hydrolases/metabolism Protein Denaturation Pyridones RNA, Transfer/isolation & purification,metabolism Ribosomes/drug effects,metabolism Temperature

Anti-Bacterial Agents Peptide Elongation Factors Pyridones Phenylalanine Guanosine Triphosphate RNA, Transfer Phosphoric Monoester Hydrolases GTP Phosphohydrolase-Linked Elongation Factors mocimycin