The pharmacology of mTOR inhibition.

Everolimus Humans Immunosuppressive Agents/pharmacology Mechanistic Target of Rapamycin Complex 1 Models, Biological Multiprotein Complexes Phosphatidylinositol 3-Kinases/metabolism Protein Binding/drug effects Protein Kinase Inhibitors/pharmacology Protein Kinases/metabolism Proteins Signal Transduction/drug effects Sirolimus/analogs & derivatives,pharmacology TOR Serine-Threonine Kinases Tacrolimus Binding Protein 1A/metabolism Transcription Factors/metabolism

CRTC2 protein, human Immunosuppressive Agents Multiprotein Complexes Protein Kinase Inhibitors Proteins Transcription Factors ridaforolimus temsirolimus Everolimus Protein Kinases MTOR protein, human Mechanistic Target of Rapamycin Complex 1 TOR Serine-Threonine Kinases Tacrolimus Binding Protein 1A Sirolimus