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PMID: 19394210 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Polysomes, P bodies and stress granules: states and fates of eukaryotic mRNAs.

Current opinion in cell biology ·Vol. 21 ·No. 3 ·2009-06-00 ·Pages 403-8

Balagopal V, Parker R

Abstract

The control of translation and mRNA degradation plays a key role in the regulation of eukaryotic gene expression. In the cytosol, mRNAs engaged in translation are distributed throughout the cytosol, while translationally inactive mRNAs can accumulate in P bodies, in complex with mRNA degradation and translation repression machinery, or in stress granules, which appear to be mRNAs stalled in translation initiation. Here we discuss how these different granules suggest a dynamic model for the metabolism of cytoplasmic mRNAs wherein they cycle between different mRNP states with different functional properties and subcellular locations.

MeSH Terms
Cytoplasmic Granules/metabolism Eukaryotic Cells/metabolism Humans Polyribosomes/metabolism Protein Biosynthesis RNA Caps/metabolism RNA Stability RNA, Messenger/metabolism Ribonucleoproteins/metabolism
Chemicals
RNA Caps RNA, Messenger Ribonucleoproteins messenger ribonucleoprotein
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Balagopal Vidya
Department of Molecular and Cellular Biology & Howard Hughes Medical Institute, University of Arizona, Tucson, AZ 85721-0206, USA.
Parker Roy
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Article Info
Journal
Current opinion in cell biology
Abbr.
Curr Opin Cell Biol
ISSN
1879-0410
DOI
10.1016/j.ceb.2009.03.005
Published
2009-06-00
Epub
2009-00-23
Pages
403-8
Language
English
Region
England
NLM ID
8913428
PMCID
PMC2740377
Subset
IM
Grants
Howard Hughes Medical Institute · United States
NIGMS NIH HHS · R37 GM045443 · United States
NIGMS NIH HHS · R37 GM045443-19 · United States
NIGMS NIH HHS · R37 GM45443 · United States
External Links
PubMed source DOI: 10.1016/j.ceb.2009.03.005 PMC Full Text View journal details
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