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PMID: 19403336 Published · ppublish English Journal Article Review

Breaking old paradigms: Th17 cells in autoimmune arthritis.

Clinical immunology (Orlando, Fla.) ·Vol. 132 ·No. 3 ·2009-09-00 ·Pages 295-304

Peck A, Mellins ED

Abstract

Aberrant helper T cell activation has been implicated in the pathogenesis of an array of autoimmune diseases. In this review, we summarize evidence that suggests the involvement of a novel T cell subset, the Th17 lineage, in rheumatoid arthritis. In particular, we focus on the role of Th17 cells in inducing and perpetuating the chronic inflammation, cartilage damage, and bone erosion that are hallmark phases of joint destruction and consider current and emerging therapies that seek to disrupt the inflammatory Th17 network and shift the immune system back towards homeostasis.

MeSH Terms
Animals Arthritis, Rheumatoid/etiology,immunology,metabolism Bone and Bones/metabolism,pathology Cartilage/metabolism,pathology Humans Interleukin-17/immunology,metabolism Models, Immunological Synovitis/etiology,immunology,metabolism T-Lymphocytes, Helper-Inducer/immunology,metabolism
Chemicals
Interleukin-17
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Peck Ariana
Department of Pediatrics, Division of Immunology and Transplantation Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. [email protected]
Mellins Elizabeth D
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Article Info
Journal
Clinical immunology (Orlando, Fla.)
Abbr.
Clin Immunol
ISSN
1521-7035
DOI
10.1016/j.clim.2009.03.522
Email
[email protected]
Published
2009-09-00
Epub
2009-00-28
Pages
295-304
Language
English
Region
United States
NLM ID
100883537
PMCID
PMC2720426
Subset
IM
Grants
NIAID NIH HHS · R21 AI075254 · United States
NIAID NIH HHS · R21 AI075253-01A2 · United States
NIAID NIH HHS · R21 AI075253-02 · United States
NIAID NIH HHS · R21 AI075254-01A1 · United States
NIAID NIH HHS · R21 AI075254-02 · United States
NIAID NIH HHS · R21 AI075253 · United States
External Links
PubMed source DOI: 10.1016/j.clim.2009.03.522 PMC Full Text View journal details
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