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PMID: 19419557 Published · epublish English Journal Article

Calcium signaling in neurodegeneration.

Molecular neurodegeneration ·Vol. 4 ·2009-05-06 ·Pages 20

Marambaud P, Dreses-Werringloer U, Vingtdeux V

Abstract

Calcium is a key signaling ion involved in many different intracellular and extracellular processes ranging from synaptic activity to cell-cell communication and adhesion. The exact definition at the molecular level of the versatility of this ion has made overwhelming progress in the past several years and has been extensively reviewed. In the brain, calcium is fundamental in the control of synaptic activity and memory formation, a process that leads to the activation of specific calcium-dependent signal transduction pathways and implicates key protein effectors, such as CaMKs, MAPK/ERKs, and CREB. Properly controlled homeostasis of calcium signaling not only supports normal brain physiology but also maintains neuronal integrity and long-term cell survival. Emerging knowledge indicates that calcium homeostasis is not only critical for cell physiology and health, but also, when deregulated, can lead to neurodegeneration via complex and diverse mechanisms involved in selective neuronal impairments and death. The identification of several modulators of calcium homeostasis, such as presenilins and CALHM1, as potential factors involved in the pathogenesis of Alzheimer's disease, provides strong support for a role of calcium in neurodegeneration. These observations represent an important step towards understanding the molecular mechanisms of calcium signaling disturbances observed in different brain diseases such as Alzheimer's, Parkinson's, and Huntington's diseases.

Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Marambaud Philippe
Litwin-Zucker Research Center for the Study of Alzheimer's Disease, The Feinstein Institute for Medical Research, North Shore-LIJ, Manhasset, New York 11030, USA. [email protected].
Dreses-Werringloer Ute
Vingtdeux Valérie
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Article Info
Journal
Molecular neurodegeneration
Abbr.
Mol Neurodegener
ISSN
1750-1326
DOI
10.1186/1750-1326-4-20
Email
[email protected]
Published
2009-05-06
Epub
2009-00-06
Pages
20
Language
English
Region
England
NLM ID
101266600
PMCID
PMC2689218
External Links
PubMed source DOI: 10.1186/1750-1326-4-20 PMC Full Text View journal details
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