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PMID: 19431343 Published · ppublish English Journal Article

A stochastic model of the repetitive activity of neurons.

Biophysical journal ·Vol. 6 ·No. 1 ·1966-01-00 ·Pages 53-69

Geisler CD, Goldberg JM

Abstract

A recurrent model of the repetitive firing of neurons responding to stimuli of long duration is given. The model assumes a deterministic threshold potential and a membrane potential which is composed of both deterministic and random components. The model accurately reproduces interval statistics obtained from different neurons discharging repetitively over a wide range of discharge rates. It is shown that the model has three important parameters; the time course of threshold recovery following a discharge, the variance of the random component, and the level of excitatory drive. The model is extended, by the use of hyperpolarizing afterpotentials, to include negative correlation between successive interspike intervals.

Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Geisler C D
Goldberg J M
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Article Info
Journal
Biophysical journal
Abbr.
Biophys J
ISSN
0006-3495
DOI
10.1016/S0006-3495(66)86639-0
Published
1966-01-00
Pages
53-69
Language
English
Region
United States
NLM ID
0370626
PMCID
PMC1367924
External Links
PubMed source DOI: 10.1016/S0006-3495(66)86639-0 PMC Full Text View journal details
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