Biochemistry. A glucose-to-gene link.

Science (New York, N.Y.) ·Vol. 324 ·No. 5930 ·2009-05-22 ·Pages 1021-2

Rathmell JC, Newgard CB

Abstract

暂无摘要

MeSH Terms

ATP Citrate (pro-S)-Lyase/genetics,metabolism Acetate-CoA Ligase/metabolism Acetyl Coenzyme A/metabolism Acetylation Animals Cell Nucleus/enzymology Cells, Cultured Chromatin/metabolism Citric Acid/metabolism Gene Expression Regulation Glucose/metabolism Glycolysis Histones/metabolism Humans Transcription, Genetic

Chemicals

Chromatin Histones Citric Acid Acetyl Coenzyme A ATP Citrate (pro-S)-Lyase Acetate-CoA Ligase Glucose

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Rathmell Jeffrey C

Department of Pharmacology and Cancer Biology, Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27710, USA.

Newgard Christopher B

References (7)

7 references, click to expand

ATP citrate lyase inhibition can suppress tumor cell growth.
Cancer Cell. 2005 Oct;8(4):311-21 PMID: 16226706
Increased activity of glycerol 3-phosphate dehydrogenase and other lipogenic enzymes in human bladder cancer.
Horm Metab Res. 2003 Oct;35(10):565-9 PMID: 14605988
Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription.
Mol Cell. 2006 Jul 21;23(2):207-17 PMID: 16857587
Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin.
Cell. 2009 Feb 6;136(3):551-64 PMID: 19185337
ATP-citrate lyase links cellular metabolism to histone acetylation.
Science. 2009 May 22;324(5930):1076-80 PMID: 19461003
ATP citrate lyase is an important component of cell growth and transformation.
Oncogene. 2005 Sep 15;24(41):6314-22 PMID: 16007201
Lipogenetic and glycolytic enzyme activities in carcinoma and nonmalignant diseases of the human breast.
Br J Cancer. 1979 Jun;39(6):681-7 PMID: 444407

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

1095-9203

DOI

10.1126/science.1174665

Published

2009-05-22

Pages

1021-2

Language

English

Region

United States

NLM ID

0404511

PMCID

PMC2788238

Subset

Grants

NCI NIH HHS · R01 CA123350 · United States

NCI NIH HHS · R01 CA123350-03 · United States

Corrections

CommentOn

PMID: 19461003

External Links

PubMed source DOI: 10.1126/science.1174665 PMC Full Text View journal details

Analysis Services

Biochemistry. A glucose-to-gene link.

Contact

WeChat Official Account