Home LiteratureArticle Details
PMID: 19461116 Published · ppublish English Journal Article Comment

Linking the genetics of type 2 diabetes with low birth weight: a role for prenatal islet maldevelopment?

Diabetes ·Vol. 58 ·No. 6 ·2009-06-00 ·Pages 1255-6

Meier JJ

Abstract

暂无摘要

MeSH Terms
Apoptosis Birth Weight DNA/genetics,isolation & purification Diabetes Mellitus, Type 2/epidemiology,genetics,pathology Fetus/physiology Humans Infant, Low Birth Weight Infant, Newborn Insulin/genetics,metabolism Insulin Secretion Insulin-Secreting Cells/pathology,physiology Mothers Risk Factors
Chemicals
Insulin DNA
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Meier Juris J
Department of Medicine I, St. Josef-Hospital, Ruhr-University of Bochum, Bochum, Germany. [email protected]
References (20)
20 references, click to expand
  1. Type 2 diabetes risk alleles are associated with reduced size at birth.
    Diabetes. 2009 Jun;58(6):1428-33 PMID: 19228808
  2. In utero undernutrition impairs rat beta-cell development.
    Diabetologia. 1997 Oct;40(10):1231-4 PMID: 9349607
  3. Ethnicity, obesity, and risk of type 2 diabetes in women: a 20-year follow-up study.
    Diabetes Care. 2006 Jul;29(7):1585-90 PMID: 16801583
  4. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
    Science. 2007 Jun 1;316(5829):1341-5 PMID: 17463248
  5. Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans.
    Diabetes. 2008 Jun;57(6):1584-94 PMID: 18334605
  6. Residual insulin positivity and pancreatic atrophy in relation to duration of chronic type 1 (insulin-dependent) diabetes mellitus and microangiopathy.
    Diabetologia. 1987 Oct;30(10):757-62 PMID: 3322901
  7. Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps.
    Diabetologia. 2008 Sep;51(9):1659-63 PMID: 18618095
  8. Combined pancreas and kidney transplantation in a lean type 2 diabetic patient. Effects on insulin secretion and sensitivity.
    Exp Clin Endocrinol Diabetes. 2002 Nov;110(8):420-4 PMID: 12518254
  9. Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.
    Diabetes. 1988 Jun;37(6):667-87 PMID: 3289989
  10. Beta cell glucose sensitivity is decreased by 39% in non-diabetic individuals carrying multiple diabetes-risk alleles compared with those with no risk alleles.
    Diabetologia. 2008 Nov;51(11):1989-92 PMID: 18719881
  11. Intrauterine growth retardation leads to the development of type 2 diabetes in the rat.
    Diabetes. 2001 Oct;50(10):2279-86 PMID: 11574409
  12. Banting lecture 1988. Role of insulin resistance in human disease.
    Diabetes. 1988 Dec;37(12):1595-607 PMID: 3056758
  13. Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes.
    Diabetologia. 2006 Aug;49(8):1838-44 PMID: 16802132
  14. Insulin effect during embryogenesis determines fetal growth: a possible molecular link between birth weight and susceptibility to type 2 diabetes.
    Diabetes. 2000 Jan;49(1):82-6 PMID: 10615953
  15. The fetal insulin hypothesis: an alternative explanation of the association of low birthweight with diabetes and vascular disease.
    Lancet. 1999 May 22;353(9166):1789-92 PMID: 10348008
  16. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
    Science. 2007 Jun 1;316(5829):1331-6 PMID: 17463246
  17. Beta cell mass in diabetes: a realistic therapeutic target?
    Diabetologia. 2008 May;51(5):703-13 PMID: 18317728
  18. Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth.
    Diabetologia. 1993 Jan;36(1):62-7 PMID: 8436255
  19. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes.
    Diabetes. 2003 Jan;52(1):102-10 PMID: 12502499
  20. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
    Science. 2007 Jun 1;316(5829):1336-41 PMID: 17463249
Article Info
Journal
Diabetes
Abbr.
Diabetes
ISSN
1939-327X
Published
2009-06-00
Pages
1255-6
Language
English
Region
United States
NLM ID
0372763
PMCID
PMC2682685
Subset
IM
Corrections
CommentOn
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]