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PMID: 19468297 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Pneumococcal serotypes and mortality following invasive pneumococcal disease: a population-based cohort study.

PLoS medicine ·Vol. 6 ·No. 5 ·2009-05-26 ·Pages e1000081

Harboe ZB, Thomsen RW, Riis A, Valentiner-Branth P, Christensen JJ, Lambertsen L, Krogfelt KA, Konradsen HB, Benfield TL

Abstract

Pneumococcal disease is a leading cause of morbidity and mortality worldwide. The aim of this study was to investigate the association between specific pneumococcal serotypes and mortality from invasive pneumococcal disease (IPD). In a nationwide population-based cohort study of IPD in Denmark during 1977-2007, 30-d mortality associated with pneumococcal serotypes was examined by multivariate logistic regression analysis after controlling for potential confounders. A total of 18,858 IPD patients were included. Overall 30-d mortality was 18%, and 3% in children younger than age 5 y. Age, male sex, meningitis, high comorbidity level, alcoholism, and early decade of diagnosis were significantly associated with mortality. Among individuals aged 5 y and older, serotypes 31, 11A, 35F, 17F, 3, 16F, 19F, 15B, and 10A were associated with highly increased mortality as compared with serotype 1 (all: adjusted odds ratio >or=3, p<0.001). In children younger than 5 y, associations between serotypes and mortality were different than in adults but statistical precision was limited because of low overall childhood-related mortality. Specific pneumococcal serotypes strongly and independently affect IPD associated mortality.

MeSH Terms
Adolescent Adult Aged Child Child, Preschool Cohort Studies Denmark/epidemiology Female Humans Logistic Models Male Middle Aged Multivariate Analysis Pneumococcal Infections/microbiology,mortality,prevention & control Pneumococcal Vaccines/immunology,therapeutic use Prevalence Serotyping Streptococcus pneumoniae/classification,isolation & purification Young Adult
Chemicals
Pneumococcal Vaccines
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Harboe Zitta B
Department of Bacteriology, Statens Serum Institut, Copenhagen. [email protected]
Thomsen Reimar W
Riis Anders
Valentiner-Branth Palle
Christensen Jens Jørgen
Lambertsen Lotte
Krogfelt Karen A
Konradsen Helle B
Benfield Thomas L
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Article Info
Journal
PLoS medicine
Abbr.
PLoS Med
ISSN
1549-1676
DOI
10.1371/journal.pmed.1000081
Email
[email protected]
Published
2009-05-26
Epub
2009-00-26
Pages
e1000081
Language
English
Region
United States
NLM ID
101231360
PMCID
PMC2680036
Subset
IM
External Links
PubMed source DOI: 10.1371/journal.pmed.1000081 PMC Full Text View journal details
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