Home LiteratureArticle Details
PMID: 1948035 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Cloning and expression of a cocaine-sensitive rat dopamine transporter.

Science (New York, N.Y.) ·Vol. 254 ·No. 5031 ·1991-10-25 ·Pages 578-9

Kilty JE, Lorang D, Amara SG

Abstract

The action of dopamine and other monoamine neurotransmitters at synapses is terminated predominantly by high-affinity reuptake into presynaptic terminals by specific sodium-dependent neurotransmitter transport proteins. A complementary DNA encoding a rat dopamine transporter has been isolated that exhibits high sequence similarity with the previously cloned norepinephrine and gamma-aminobutyric acid transporters. Transient expression of the complementary DNA in HeLa cells confirms the cocaine sensitivity of this transporter.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Carrier Proteins/drug effects,genetics,metabolism Cloning, Molecular Cocaine/pharmacology Dopamine/metabolism Dopamine Plasma Membrane Transport Proteins Gene Expression HeLa Cells Humans Kinetics Membrane Glycoproteins Membrane Transport Proteins Molecular Sequence Data Nerve Tissue Proteins Oligodeoxyribonucleotides Polymerase Chain Reaction/methods Rats Sequence Homology, Nucleic Acid Transfection
Chemicals
Carrier Proteins Dopamine Plasma Membrane Transport Proteins Membrane Glycoproteins Membrane Transport Proteins Nerve Tissue Proteins Oligodeoxyribonucleotides Cocaine Dopamine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kilty J E
Yale University, New Haven, CT 06510.
Lorang D
Amara S G
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.1948035
Published
1991-10-25
Pages
578-9
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Databases
GENBANK
M76239, M76240, M76241, M76242, M76243, M76244, M80233, M83741, M83742, S70464
External Links
PubMed source DOI: 10.1126/science.1948035 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2