Protection against herpes simplex virus infection in mice by Corynebacterium parvum.

Infection and immunity ·Vol. 16 ·No. 1 ·1977-04-00 ·Pages 9-11

Kirchner H, Hirt HM, Munk K

Abstract

Corynebacterium parvum administered in mice prior to herpes simplex virus (HSV) infection significantly protected them against lethal encephalitis. This was seen both with a mouse strain highly susceptible to HSV and with one relatively resistant to HSV. Mice immunosuppressed by cyclophosphamide and showing an increased mortality after HSV infection were also protected by C. parvum pretreatment. However, C. parvum given simultaneously with or after HSV infection did not exert a therapeutic effect.

MeSH Terms

Animals Cyclophosphamide/pharmacology Encephalitis/prevention & control,therapy Female Herpesviridae Infections/prevention & control,therapy Immunotherapy Male Mice Mice, Inbred C57BL Mice, Inbred Strains Propionibacterium acnes/immunology Time Factors

Chemicals

Cyclophosphamide

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Kirchner H

Hirt H M

Munk K

References (11)

11 references, click to expand

Pathogenesis of recurrent herpes simplex infections.
J Invest Dermatol. 1975 Oct;65(4):341-6 PMID: 1176786
[CYTOPATHIC EFFECT AND PLAQUE MORPHOLOGY OF VARIOUS HERPES SIMPLEX VIRUS STRAINS].
Arch Gesamte Virusforsch. 1963 Aug 26;13:529-40 PMID: 14078843
Genetics of natural resistance to herpesvirus infections in mice.
Nature. 1975 Nov 13;258(5531):152-3 PMID: 171586
Effects of immunostimulants on resistance of newborn mice to herpes simplex type 2 infection.
Proc Soc Exp Biol Med. 1976 May;152(1):57-60 PMID: 177992
[Corynebacterium parvum in advanced cancers. 1st evaluation of the therapeutic activity of this immunostimulin].
Nouv Presse Med. 1972 Jan 1;1(1):19-23 PMID: 4110695
On the role of mononuclear phagocytes in immunity against viruses.
Prog Med Virol. 1974;18(0):15-31 PMID: 4213926
Selective effects of anti-macrophage serum, silica and anti-lymphocyte serum on pathogenesis of herpes virus infection of young adult mice.
J Immunol. 1970 May;104(5):1155-9 PMID: 4315460
Question: do herpesviruses cause cancer? Answer: of course they do.
J Natl Cancer Inst. 1973 Apr;50(4):825-32 PMID: 4350025
Corynebacterium parvum as an immunotherapeutic anticancer agent.
Semin Oncol. 1974 Dec;1(4):367-78 PMID: 4620441
Herpes simplex vaccines.
Cancer Res. 1976 Feb;36(2 pt 2):857-8 PMID: 56228
Immunology of herpes simplex virus infection: relevance to herpes simplex virus vaccines and cervical cancer.
Cancer Res. 1976 Feb;36(2 pt 2):836-44 PMID: 766960

Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.16.1.9-11.1977

Published

1977-04-00

Pages

9-11

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC421479

Subset

External Links

PubMed source DOI: 10.1128/iai.16.1.9-11.1977 PMC Full Text View journal details

Analysis Services

Protection against herpes simplex virus infection in mice by Corynebacterium parvum.

Contact

WeChat Official Account