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PMID: 19505534 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Sorting out the functional role(s) of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) in cell proliferation and cancer.

Biochimica et biophysica acta ·Vol. 1796 ·No. 2 ·2009-12-00 ·Pages 230-41

Peters JM, Gonzalez FJ

Abstract

Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) has many beneficial physiological functions ranging from enhancing fatty acid catabolism, improving insulin sensitivity, inhibiting inflammation and increasing oxidative myofibers allowing for improved athletic performance. Thus, given the potential for targeting PPARbeta/delta for the prevention and/or treatment of diseases including diabetes, dyslipidemias, metabolic syndrome and cancer, it is critical to clarify the functional role of PPARbeta/delta in cell proliferation and associated disorders such as cancer. However, there is considerable controversy whether PPARbeta/delta stimulates or inhibits cell proliferation. This review summarizes the literature describing the influence of PPARbeta/delta on cell proliferation, with an emphasis toward dissecting the data that give rise to opposing hypotheses. Suggestions are offered to standardize measurements associated with these studies so that interlaboratory comparisons can be accurately assessed.

MeSH Terms
Animals Apoptosis Cell Differentiation Cell Proliferation Humans Keratinocytes/cytology,physiology Neoplasms/pathology PPAR delta/physiology PPAR-beta/physiology Skin/cytology
Chemicals
PPAR delta PPAR-beta
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Peters Jeffrey M
Department of Veterinary and Biomedical Sciences and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA. [email protected]
Gonzalez Frank J
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Article Info
Journal
Biochimica et biophysica acta
Abbr.
Biochim Biophys Acta
ISSN
0006-3002
DOI
10.1016/j.bbcan.2009.06.002
Email
[email protected]
Published
2009-12-00
Epub
2009-00-06
Pages
230-41
Language
English
Region
Netherlands
NLM ID
0217513
PMCID
PMC2762441
Subset
IM
Grants
NCI NIH HHS · R01 CA124533 · United States
NCI NIH HHS · R01 CA097999 · United States
NCI NIH HHS · R01 CA124533-03 · United States
NCI NIH HHS · R01 CA124533-02 · United States
NCI NIH HHS · R01 CA097999-05 · United States
External Links
PubMed source DOI: 10.1016/j.bbcan.2009.06.002 PMC Full Text
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