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PMID: 19513708 Published · ppublish English Journal Article Review

Homer and the ryanodine receptor.

European biophysics journal : EBJ ·Vol. 39 ·No. 1 ·2009-12-00 ·Pages 91-102

Pouliquin P, Dulhunty AF

Abstract

Homer proteins have recently been identified as novel high-affinity ligands that modulate ryanodine receptor (RyR) Ca(2+) release channels in heart and skeletal muscle, through an EVH1 domain which binds to proline-rich regions in target proteins. Many Homer proteins can also self-associate through a coiled-coil domain that allows their multimerisation. In other tissues, especially neurons, Homer anchors proteins embedded in the surface membrane to the Ca(2+) release channel in the endoplasmic reticulum and can anchor membrane or cytosolic proteins to the cytoskeleton. Although this anchoring aspect of Homer function has not been extensively investigated in muscle, there are consensus sequences for Homer binding in the RyR and on many of the proteins that it interacts with in the massive RyR ion channel complex. In this review we explore the potential of Homer to contribute to a variety of cell processes in muscle and neurons that also involve RyR channels.

MeSH Terms
Amino Acid Sequence Animals Carrier Proteins/chemistry,metabolism Homer Scaffolding Proteins Humans Intracellular Space/metabolism Ligands Molecular Sequence Data Protein Transport Ryanodine Receptor Calcium Release Channel/chemistry,metabolism
Chemicals
Carrier Proteins Homer Scaffolding Proteins Ligands Ryanodine Receptor Calcium Release Channel
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Pouliquin Pierre
Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra, ACT, 2601, Australia.
Dulhunty Angela Fay
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Article Info
Journal
European biophysics journal : EBJ
Abbr.
Eur Biophys J
ISSN
1432-1017
DOI
10.1007/s00249-009-0494-1
Published
2009-12-00
Epub
2009-00-10
Pages
91-102
Language
English
Region
Germany
NLM ID
8409413
Subset
IM
External Links
PubMed source DOI: 10.1007/s00249-009-0494-1 View journal details
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