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PMID: 19524504 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

p62 at the crossroads of autophagy, apoptosis, and cancer.

Cell ·Vol. 137 ·No. 6 ·2009-06-12 ·Pages 1001-4

Moscat J, Diaz-Meco MT

Abstract

The signaling adaptor p62 is a multidomain protein implicated in the activation of the transcription factor NF-kappaB. Recent findings link p62 activity to the extrinsic apoptosis pathway, and Mathew et al. (2009) now show that the modulation of p62 by autophagy is a key factor in tumorigenesis. These findings place p62 at critical decision points that control cell death and survival.

MeSH Terms
Adaptor Proteins, Signal Transducing/metabolism Apoptosis Autophagy Humans NF-kappa B/metabolism Neoplasms/metabolism Sequestosome-1 Protein
Chemicals
Adaptor Proteins, Signal Transducing NF-kappa B SQSTM1 protein, human Sequestosome-1 Protein
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Moscat Jorge
Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. [email protected]
Diaz-Meco Maria T
References (20)
20 references, click to expand
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Article Info
Journal
Cell
Abbr.
Cell
ISSN
1097-4172
DOI
10.1016/j.cell.2009.05.023
Email
[email protected]
Published
2009-06-12
Pages
1001-4
Language
English
Region
United States
NLM ID
0413066
PMCID
PMC3971861
Subset
IM
Grants
NIAID NIH HHS · R01 AI072581 · United States
NCI NIH HHS · R01 CA134530 · United States
NIAID NIH HHS · R01-AI072581 · United States
NCI NIH HHS · R01-CA134530 · United States
External Links
PubMed source DOI: 10.1016/j.cell.2009.05.023 PMC Full Text View journal details
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