Home LiteratureArticle Details
PMID: 19529824 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Calcium and calmodulin-mediated regulation of gene expression in plants.

Molecular plant ·Vol. 2 ·No. 1 ·2009-01-00 ·Pages 13-21

Kim MC, Chung WS, Yun DJ, Cho MJ

Abstract

Sessile plants have developed a very delicate system to sense diverse kinds of endogenous developmental cues and exogenous environmental stimuli by using a simple Ca2+ ion. Calmodulin (CaM) is the predominant Ca2+ sensor and plays a crucial role in decoding the Ca2+ signatures into proper cellular responses in various cellular compartments in eukaryotes. A growing body of evidence points to the importance of Ca2+ and CaM in the regulation of the transcriptional process during plant responses to endogenous and exogenous stimuli. Here, we review recent progress in the identification of transcriptional regulators modulated by Ca2+ and CaM and in the assessment of their functional significance during plant signal transduction in response to biotic and abiotic stresses and developmental cues.

Keywords
Abiotic/environmental stress calcium signaling/transport gene expression
MeSH Terms
Calcium/physiology Calcium Signaling Calmodulin/physiology Cell Nucleus/physiology Gene Expression Regulation, Plant/physiology
Chemicals
Calmodulin Calcium
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Kim Min Chul
Division of Applied Life Science (BK21 Program), Plant Molecular Biology and Biotechnology Research Center and Environmental Biotechnology National Core Research Center, Gyeongsang National University, Jinju 660-701, Korea. [email protected]
Chung Woo Sik
Yun Dae-Jin
Cho Moo Je
References (70)
70 references, click to expand
  1. Calcium in plants.
    Ann Bot. 2003 Oct;92(4):487-511 PMID: 12933363
  2. Control of free calcium in plant cell nuclei.
    Nature. 2000 Jun 15;405(6788):754-5 PMID: 10866186
  3. The calmodulin-binding protein kinase 3 is part of heat-shock signal transduction in Arabidopsis thaliana.
    Plant J. 2008 Sep;55(5):760-73 PMID: 18466301
  4. Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor.
    J Biol Chem. 2004 Jan 9;279(2):1491-8 PMID: 14573596
  5. Identification of a calmodulin-binding NAC protein as a transcriptional repressor in Arabidopsis.
    J Biol Chem. 2007 Dec 14;282(50):36292-302 PMID: 17947243
  6. Purification and partial characterization of a calmodulin-stimulated nucleoside triphosphatase from pea nuclei.
    J Biol Chem. 1987 Aug 5;262(22):10689-94 PMID: 3038893
  7. Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1.
    EMBO J. 2001 Jul 16;20(14):3800-10 PMID: 11447121
  8. Functional analysis of a calcium-binding transcription factor involved in plant salt stress signaling.
    FEBS Lett. 2006 Oct 2;580(22):5251-6 PMID: 16962584
  9. Calcium channels in higher plants.
    Biochim Biophys Acta. 2000 May 1;1465(1-2):171-89 PMID: 10748253
  10. Calmodulin-binding transcription activator (CAMTA) 3 mediates biotic defense responses in Arabidopsis.
    FEBS Lett. 2008 Mar 19;582(6):943-8 PMID: 18298954
  11. p300/CBP proteins: HATs for transcriptional bridges and scaffolds.
    J Cell Sci. 2001 Jul;114(Pt 13):2363-73 PMID: 11559745
  12. Mg2+ and Ca2+ differentially regulate DNA binding and dimerization of DREAM.
    J Biol Chem. 2005 May 6;280(18):18008-14 PMID: 15746104
  13. Does aluminum inhibit pollen germination via extracellular calmodulin?
    Plant Cell Physiol. 2000 Mar;41(3):372-6 PMID: 10805602
  14. WRKY group IId transcription factors interact with calmodulin.
    FEBS Lett. 2005 Feb 28;579(6):1545-50 PMID: 15733871
  15. A novel family of calmodulin-binding transcription activators in multicellular organisms.
    J Biol Chem. 2002 Jun 14;277(24):21851-61 PMID: 11925432
  16. WRKY transcription factors: from DNA binding towards biological function.
    Curr Opin Plant Biol. 2004 Oct;7(5):491-8 PMID: 15337090
  17. Extracellular calmodulin-induced stomatal closure is mediated by heterotrimeric G protein and H2O2.
    Plant Physiol. 2004 Dec;136(4):4096-103 PMID: 15557100
  18. ICE1: a regulator of cold-induced transcriptome and freezing tolerance in Arabidopsis.
    Genes Dev. 2003 Apr 15;17(8):1043-54 PMID: 12672693
  19. Calcium/calmodulin-mediated signal network in plants.
    Trends Plant Sci. 2003 Oct;8(10):505-12 PMID: 14557048
  20. A novel yeast two-hybrid approach to identify CDPK substrates: characterization of the interaction between AtCPK11 and AtDi19, a nuclear zinc finger protein.
    FEBS Lett. 2006 Feb 6;580(3):904-11 PMID: 16438971
  21. A calmodulin binding protein from Arabidopsis is induced by ethylene and contains a DNA-binding motif.
    Biochem Biophys Res Commun. 2000 Dec 29;279(3):762-9 PMID: 11162426
  22. Calmodulins and calcineurin B-like proteins: calcium sensors for specific signal response coupling in plants.
    Plant Cell. 2002;14 Suppl:S389-400 PMID: 12045290
  23. A novel family of Ca2+/calmodulin-binding proteins involved in transcriptional regulation: interaction with fsh/Ring3 class transcription activators.
    Plant Mol Biol. 2004 Mar;54(4):549-69 PMID: 15316289
  24. Arabidopsis CAMTA family proteins enhance V-PPase expression in pollen.
    Plant Cell Physiol. 2003 Oct;44(10):975-81 PMID: 14581622
  25. Plant-specific calmodulin-binding proteins.
    Annu Rev Plant Biol. 2005;56:435-66 PMID: 15862103
  26. CG-1, a parsley light-induced DNA-binding protein.
    Plant Mol Biol. 1994 Aug;25(5):921-4 PMID: 8075408
  27. Calcium at the crossroads of signaling.
    Plant Cell. 2002;14 Suppl:S401-17 PMID: 12045291
  28. The nucleus together with the cytosol generates patterns of specific cellular calcium signatures in tobacco suspension culture cells.
    Cell Calcium. 2001 Dec;30(6):413-21 PMID: 11728136
  29. Direct interaction of a divergent CaM isoform and the transcription factor, MYB2, enhances salt tolerance in arabidopsis.
    J Biol Chem. 2005 Feb 4;280(5):3697-706 PMID: 15569682
  30. DRL1, a homolog of the yeast TOT4/KTI12 protein, has a function in meristem activity and organ growth in plants.
    Plant Cell. 2003 Mar;15(3):639-54 PMID: 12615938
  31. CAMTAs: calmodulin-binding transcription activators from plants to human.
    FEBS Lett. 2007 Aug 21;581(21):3893-8 PMID: 17689537
  32. Calcium signaling through protein kinases. The Arabidopsis calcium-dependent protein kinase gene family.
    Plant Physiol. 2002 Jun;129(2):469-85 PMID: 12068094
  33. Molecular genetic perspectives on cross-talk and specificity in abiotic stress signalling in plants.
    J Exp Bot. 2004 Jan;55(395):225-36 PMID: 14673035
  34. NAC transcription factors: structurally distinct, functionally diverse.
    Trends Plant Sci. 2005 Feb;10(2):79-87 PMID: 15708345
  35. A Ca2+- and voltage-dependent cation channel in the nuclear envelope of red beet.
    Biochim Biophys Acta. 1998 Oct 15;1375(1-2):117-30 PMID: 9767144
  36. Calmodulin in action: diversity in target recognition and activation mechanisms.
    Cell. 2002 Mar 22;108(6):739-42 PMID: 11955428
  37. The prenylation status of a novel plant calmodulin directs plasma membrane or nuclear localization of the protein.
    EMBO J. 1999 Apr 1;18(7):1996-2007 PMID: 10202162
  38. Isolation and characterization of a novel calmodulin-binding protein from potato.
    J Biol Chem. 2002 Feb 8;277(6):4206-14 PMID: 11684678
  39. Calmodulin isoforms differentially enhance the binding of cauliflower nuclear proteins and recombinant TGA3 to a region derived from the Arabidopsis Cam-3 promoter.
    Plant Cell. 1996 Jun;8(6):1069-77 PMID: 8672891
  40. A stress-induced calcium-dependent protein kinase from Mesembryanthemum crystallinum phosphorylates a two-component pseudo-response regulator.
    Plant J. 2000 Dec;24(5):679-91 PMID: 11123806
  41. Regulation of a recombinant pea nuclear apyrase by calmodulin and casein kinase II.
    Biochim Biophys Acta. 2000 Dec 1;1494(3):248-55 PMID: 11121582
  42. BcLTP, a novel lipid transfer protein in Brassica chinensis, may secrete and combine extracellular CaM.
    Plant Cell Rep. 2008 Jan;27(1):159-69 PMID: 17891402
  43. The role of calcium-binding proteins in the control of transcription: structure to function.
    Bioessays. 2002 Jul;24(7):625-36 PMID: 12111723
  44. DREAM is a Ca2+-regulated transcriptional repressor.
    Nature. 1999 Mar 4;398(6722):80-4 PMID: 10078534
  45. A basic helix-loop-helix transcription factor in Arabidopsis, MYC2, acts as a repressor of blue light-mediated photomorphogenic growth.
    Plant Cell. 2005 Jul;17(7):1953-66 PMID: 15923349
  46. Identification of pirin, a novel highly conserved nuclear protein.
    J Biol Chem. 1997 Mar 28;272(13):8482-9 PMID: 9079676
  47. Pathogen-induced Arabidopsis WRKY7 is a transcriptional repressor and enhances plant susceptibility to Pseudomonas syringae.
    Plant Physiol. 2006 Nov;142(3):1180-92 PMID: 16963526
  48. A novel calmodulin-binding protein functions as a negative regulator of osmotic stress tolerance in Arabidopsis thaliana seedlings.
    Plant J. 2004 May;38(3):410-20 PMID: 15086802
  49. Involvement of specific calmodulin isoforms in salicylic acid-independent activation of plant disease resistance responses.
    Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):766-71 PMID: 9892708
  50. Salt and drought stress signal transduction in plants.
    Annu Rev Plant Biol. 2002;53:247-73 PMID: 12221975
  51. Calcium- and salt-stress signaling in plants: shedding light on SOS pathway.
    Arch Biochem Biophys. 2008 Mar 15;471(2):146-58 PMID: 18241665
  52. Subcellular targeting of nine calcium-dependent protein kinase isoforms from Arabidopsis.
    Plant Physiol. 2003 Aug;132(4):1840-8 PMID: 12913141
  53. An early ethylene up-regulated gene encoding a calmodulin-binding protein involved in plant senescence and death.
    J Biol Chem. 2000 Dec 8;275(49):38467-73 PMID: 10952977
  54. A basic leucine zipper transcription factor, G-box-binding factor 1, regulates blue light-mediated photomorphogenic growth in Arabidopsis.
    J Biol Chem. 2006 Aug 4;281(31):22190-22199 PMID: 16638747
  55. Calcium oscillations in higher plants.
    Curr Opin Plant Biol. 2001 Oct;4(5):415-20 PMID: 11597499
  56. Calmodulin7 plays an important role as transcriptional regulator in Arabidopsis seedling development.
    Plant Cell. 2008 Jul;20(7):1747-59 PMID: 18621945
  57. Isolated plant nuclei as mechanical and thermal sensors involved in calcium signalling.
    Plant J. 2004 Oct;40(1):12-21 PMID: 15361137
  58. Characterization of a cDNA coding for an extracellular calmodulin-binding protein from suspension-cultured cells of Angelica dahurica.
    Planta. 2005 Oct;222(3):428-37 PMID: 15891898
  59. Decoding Ca(2+) signals through plant protein kinases.
    Annu Rev Plant Biol. 2004;55:263-88 PMID: 15377221
  60. A calmodulin-binding/CGCG box DNA-binding protein family involved in multiple signaling pathways in plants.
    J Biol Chem. 2002 Nov 22;277(47):45049-58 PMID: 12218065
  61. Stimulation of the blue light phototropic receptor NPH1 causes a transient increase in cytosolic Ca2+.
    Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13554-9 PMID: 10557359
  62. Modulation of Calmodulin mRNA and Protein Levels in Barley Aleurone.
    Plant Physiol. 1996 Jun;111(2):371-380 PMID: 12226294
  63. Isolation of a calmodulin-binding transcription factor from rice (Oryza sativa L.).
    J Biol Chem. 2005 Dec 9;280(49):40820-31 PMID: 16192280
  64. Genes encoding calmodulin-binding proteins in the Arabidopsis genome.
    J Biol Chem. 2002 Mar 22;277(12):9840-52 PMID: 11782485
  65. Domain analysis of a groundnut calcium-dependent protein kinase: nuclear localization sequence in the junction domain is coupled with nonconsensus calcium binding domains.
    J Biol Chem. 2006 Apr 14;281(15):10399-409 PMID: 16464867
  66. Calmodulin-binding protein phosphatase PP7 is involved in thermotolerance in Arabidopsis.
    Plant Cell Environ. 2007 Feb;30(2):156-64 PMID: 17238907
  67. Distribution of calmodulin in pea seedlings: immunocytochemical localization in plumules and root apices.
    Planta. 1986;168:461-70 PMID: 11539095
  68. Autonomous regulation of free Ca2+ concentrations in isolated plant cell nuclei: a mathematical analysis.
    Cell Calcium. 2006 Apr;39(4):293-303 PMID: 16473405
  69. Encoding specificity in plant calcium signalling: hot-spotting the ups and downs and waves.
    Ann Bot. 2003 Oct;92(4):477-85 PMID: 12933365
  70. An Arabidopsis gene family encoding DRE/CRT binding proteins involved in low-temperature-responsive gene expression.
    Biochem Biophys Res Commun. 1998 Sep 8;250(1):161-70 PMID: 9735350
Article Info
Journal
Molecular plant
Abbr.
Mol Plant
ISSN
1674-2052
DOI
10.1093/mp/ssn091
Email
[email protected]
Published
2009-01-00
Epub
2009-00-06
Pages
13-21
Language
English
Region
England
NLM ID
101465514
PMCID
PMC2639735
Subset
IM
External Links
PubMed source DOI: 10.1093/mp/ssn091 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2