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PMID: 19535999 Published · ppublish English Case Reports Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury.

Journal of neuropathology and experimental neurology ·Vol. 68 ·No. 7 ·2009-07-00 ·Pages 709-35

McKee AC, Cantu RC, Nowinski CJ, Hedley-Whyte ET, Gavett BE, Budson AE, Santini VE, Lee HS, Kubilus CA, Stern RA

Abstract

Since the 1920s, it has been known that the repetitive brain trauma associated with boxing may produce a progressive neurological deterioration, originally termed dementia pugilistica, and more recently, chronic traumatic encephalopathy (CTE). We review 48 cases of neuropathologically verified CTE recorded in the literature and document the detailed findings of CTE in 3 profession althletes, 1 football player and 2 boxers. Clinically, CTE is associated with memory disturbances, behavioral and personality changes, parkinsonism, and speech and gait abnormalities. Neuropathologically, CTE is characterized by atrophy of the cerebral hemispheres, medial temporal lobe, thalamus, mammillary bodies, and brainstem, with ventricular dilatation and a fenestrated cavum septum pellucidum. Microscopically, there are extensive tau-immunoreactive neurofibrillary tangles, astrocytic tangles, and spindle-shaped and threadlike neurites throughout the brain. The neurofibrillary degeneration of CTE is distinguished from other tauopathies by preferential involvement of the superficial cortical layers, irregular patchy distribution in the frontal and temporal cortices, propensity for sulcal depths, prominent perivascular, periventricular, and subpial distribution, and marked accumulation of tau-immunoreactive astrocytes. Deposition of beta-amyloid, most commonly as diffuse plaques, occurs in fewer than half the cases. Chronic traumatic encephalopathy is a neuropathologically distinct slowly progressive tauopathy with a clear environmental etiology.

MeSH Terms
Adult Aged Aged, 80 and over Amyloid beta-Peptides/analysis Apolipoprotein E4/genetics Athletic Injuries/complications Brain/pathology Brain Chemistry Brain Injury, Chronic/etiology,pathology,physiopathology Cell Death Disease Progression Female Genetic Predisposition to Disease Head Injuries, Closed/complications Humans Male Middle Aged Neurons/pathology,physiology Sports Tauopathies/etiology,pathology,physiopathology
Chemicals
Amyloid beta-Peptides Apolipoprotein E4
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
McKee Ann C
Department of Neurology, Center for the Study of Traumatic Encephalopathy, Boston University School of Medicine, Boston, MA, USA. [email protected]
Cantu Robert C
Nowinski Christopher J
Hedley-Whyte E Tessa
Gavett Brandon E
Budson Andrew E
Santini Veronica E
Lee Hyo-Soon
Kubilus Caroline A
Stern Robert A
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Article Info
Journal
Journal of neuropathology and experimental neurology
Abbr.
J Neuropathol Exp Neurol
ISSN
0022-3069
Published
2009-07-00
Pages
709-35
Language
English
Region
England
NLM ID
2985192R
PMCID
PMC2945234
Subset
IM
Grants
NIA NIH HHS · P30 AG013846 · United States
NIA NIH HHS · P30 AG013846-129003 · United States
NIA NIH HHS · P30 AG013846-139003 · United States
NIA NIH HHS · P30 AG13846 · United States
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