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PMID: 19538926 Published · ppublish English Journal Article Comment

Knocking in the NLRP3 inflammasome.

Immunity ·Vol. 30 ·No. 6 ·2009-06-19 ·Pages 761-3

Girardin SE

Abstract

Mutations in the human NLRP3 gene cause interleukin-1beta-related autoinflammatory syndromes. In this issue of Immunity, Brydges et al. (2009) and Meng et al. (2009) report the characterization of Nlrp3 gene-targeted mice harboring mutations mimicking those causing disease in humans.

MeSH Terms
Animals Carrier Proteins/genetics,immunology,metabolism Gene Knock-In Techniques Inflammation/genetics Interleukin-1beta/immunology,metabolism Mice NLR Family, Pyrin Domain-Containing 3 Protein T-Lymphocytes, Helper-Inducer/immunology,metabolism
Chemicals
Carrier Proteins Interleukin-1beta NLR Family, Pyrin Domain-Containing 3 Protein Nlrp3 protein, mouse
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Girardin Stephen E
Department of Laboratory Medicine and Pathobiology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada. [email protected]
Article Info
Journal
Immunity
Abbr.
Immunity
ISSN
1097-4180
DOI
10.1016/j.immuni.2009.06.001
Email
[email protected]
Published
2009-06-19
Pages
761-3
Language
English
Region
United States
NLM ID
9432918
Subset
IM
Corrections
CommentOn
PMID: 19501000
CommentOn
PMID: 19501001
External Links
PubMed source DOI: 10.1016/j.immuni.2009.06.001 View journal details
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