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PMID: 19590004 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

A functional role for adult hippocampal neurogenesis in spatial pattern separation.

Science (New York, N.Y.) ·Vol. 325 ·No. 5937 ·2009-07-10 ·Pages 210-3

Clelland CD, Choi M, Romberg C, Clemenson GD, Fragniere A, Tyers P, Jessberger S, Saksida LM, Barker RA, Gage FH, Bussey TJ

Abstract

The dentate gyrus (DG) of the mammalian hippocampus is hypothesized to mediate pattern separation-the formation of distinct and orthogonal representations of mnemonic information-and also undergoes neurogenesis throughout life. How neurogenesis contributes to hippocampal function is largely unknown. Using adult mice in which hippocampal neurogenesis was ablated, we found specific impairments in spatial discrimination with two behavioral assays: (i) a spatial navigation radial arm maze task and (ii) a spatial, but non-navigable, task in the mouse touch screen. Mice with ablated neurogenesis were impaired when stimuli were presented with little spatial separation, but not when stimuli were more widely separated in space. Thus, newborn neurons may be necessary for normal pattern separation function in the DG of adult mice.

MeSH Terms
Animals Cues Dentate Gyrus/cytology,physiology Discrimination Learning/physiology Female Hippocampus/cytology,physiology Maze Learning Memory/physiology Mice Mice, Inbred C57BL Neurogenesis Neurons/physiology Psychomotor Performance Space Perception
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Clelland C D
Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Choi M
Romberg C
Clemenson G D
Fragniere A
Tyers P
Jessberger S
Saksida L M
Barker R A
Gage F H
Bussey T J
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Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
Published
2009-07-10
Pages
210-3
Language
English
Region
United States
NLM ID
0404511
PMCID
PMC2997634
Subset
IM
Grants
Medical Research Council · G0001354 · United Kingdom
NINDS NIH HHS · R01 NS050217 · United States
NINDS NIH HHS · R01 NS050217-05 · United States
NINDS NIH HHS · NS-050217 · United States
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