-
Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors.
Science. 1998 Jan 23;279(5350):577-80
PMID: 9438854
-
Coexpression of the c-kit and stem cell factor genes in breast carcinomas.
Cell Growth Differ. 1995 Jun;6(6):769-79
PMID: 7545433
-
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces.
Nature. 2007 Dec 13;450(7172):1001-9
PMID: 18075579
-
Disruption of protein-protein interactions using nanoparticles: inhibition of cytochrome c peroxidase.
Chem Commun (Camb). 2006 Apr 7;(13):1390-2
PMID: 16550276
-
Small-molecule inhibitors of protein-protein interactions: progressing towards the dream.
Nat Rev Drug Discov. 2004 Apr;3(4):301-17
PMID: 15060526
-
The biology of stem cell factor and its receptor C-kit.
Int J Biochem Cell Biol. 1999 Oct;31(10):1037-51
PMID: 10582338
-
Strategies for targeting protein-protein interactions with synthetic agents.
Angew Chem Int Ed Engl. 2005 Jul 4;44(27):4130-63
PMID: 15954154
-
Benzoylurea oligomers: synthetic foldamers that mimic extended alpha helices.
Angew Chem Int Ed Engl. 2007;46(45):8614-7
PMID: 17918270
-
Porphyrin analogues as novel antagonists of fibroblast growth factor and vascular endothelial growth factor receptor binding that inhibit endothelial cell proliferation, tumor progression, and metastasis.
Cancer Res. 2000 Jun 1;60(11):2973-80
PMID: 10850445
-
Helix mimetics as inhibitors of the interaction of the estrogen receptor with coactivator peptides.
Angew Chem Int Ed Engl. 2007;46(24):4471-3
PMID: 17487924
-
Lack of KIT or FMS internal tandem duplications but co-expression with ligands in AML.
Leuk Res. 2004 Feb;28(2):121-6
PMID: 14654075
-
Facial control of nanoparticle binding to cytochrome C.
J Am Chem Soc. 2007 Mar 14;129(10):2732-3
PMID: 17309259
-
Protein surface recognition by synthetic receptors based on a tetraphenylporphyrin scaffold.
Org Lett. 2000 Jun 15;2(12):1721-3
PMID: 10880210
-
A journey in structure-based drug discovery: from designed peptides to protein surface topomimetics as antibiotic and antiangiogenic agents.
Acc Chem Res. 2007 Oct;40(10):1057-65
PMID: 17661438
-
beta-Peptides as inhibitors of protein-protein interactions.
Bioorg Med Chem. 2005 Jan 3;13(1):11-6
PMID: 15582447
-
Foldamers as versatile frameworks for the design and evolution of function.
Nat Chem Biol. 2007 May;3(5):252-62
PMID: 17438550
-
Terphenyl-Based Bak BH3 alpha-helical proteomimetics as low-molecular-weight antagonists of Bcl-xL.
J Am Chem Soc. 2005 Jul 27;127(29):10191-6
PMID: 16028929
-
Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice.
Nat Biotechnol. 2000 Oct;18(10):1065-70
PMID: 11017044
-
Protein surface recognition by rational design: nanomolar ligands for potassium channels.
J Am Chem Soc. 2003 Oct 22;125(42):12668-9
PMID: 14558789
-
Development trends for monoclonal antibody cancer therapeutics.
Nat Rev Drug Discov. 2007 May;6(5):349-56
PMID: 17431406
-
Controlling curvature in a family of oligoamide alpha-helix mimetics.
Angew Chem Int Ed Engl. 2008;47(50):9691-4
PMID: 18989875
-
Kit receptor dimerization is driven by bivalent binding of stem cell factor.
J Biol Chem. 1997 Mar 7;272(10):6311-7
PMID: 9045650
-
Synthetic non-peptide mimetics of alpha-helices.
Chem Soc Rev. 2007 Feb;36(2):326-34
PMID: 17264933
-
Small-molecule kinase-inhibitor target assessment.
Chembiochem. 2005 Mar;6(3):523-6
PMID: 15696508
-
Foldamers with heterogeneous backbones.
Acc Chem Res. 2008 Oct;41(10):1399-408
PMID: 18590282
-
Modulation of protein-protein interactions by synthetic receptors: design of molecules that disrupt serine protease-proteinaceous inhibitor interaction.
Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5105-9
PMID: 11959960
-
Toward proteomimetics: terphenyl derivatives as structural and functional mimics of extended regions of an alpha-helix.
J Am Chem Soc. 2001 Jun 6;123(22):5382-3
PMID: 11457415
-
Catalytic unfolding and proteolysis of cytochrome C induced by synthetic binding agents.
J Am Chem Soc. 2004 Oct 13;126(40):12833-42
PMID: 15469279
-
Beyond Herceptin and Gleevec.
Curr Opin Chem Biol. 2003 Aug;7(4):490-5
PMID: 12941424
-
Familial gastrointestinal stromal tumours with germline mutation of the KIT gene.
Nat Genet. 1998 Aug;19(4):323-4
PMID: 9697690
-
Structure-activity studies on a library of potent calix[4]arene-based PDGF antagonists that inhibit PDGF-stimulated PDGFR tyrosine phosphorylation.
Org Biomol Chem. 2006 Jun 21;4(12):2376-86
PMID: 16763682
-
Molecular characterization of PDGFR-alpha/PDGF-A and c-KIT/SCF in gliosarcomas.
Cell Oncol. 2005;27(5-6):319-26
PMID: 16373964
-
Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor.
Cell. 2007 Jul 27;130(2):323-34
PMID: 17662946
-
Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction.
Angew Chem Int Ed Engl. 2005 Apr 29;44(18):2704-2707
PMID: 15765497
-
Directed denaturation: room temperature and stoichiometric unfolding of cytochrome C by a metalloporphyrin dimer.
J Am Chem Soc. 2003 Apr 16;125(15):4420-1
PMID: 12683802
-
Targeting protein-protein interactions by rational design: mimicry of protein surfaces.
J R Soc Interface. 2006 Apr 22;3(7):215-33
PMID: 16849232