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PMID: 19668247 Published · ppublish English Journal Article Review

Insights from genomic profiling of transcription factors.

Nature reviews. Genetics ·Vol. 10 ·No. 9 ·2009-09-00 ·Pages 605-16

Farnham PJ

Abstract

A crucial question in the field of gene regulation is whether the location at which a transcription factor binds influences its effectiveness or the mechanism by which it regulates transcription. Comprehensive transcription factor binding maps are needed to address these issues, and genome-wide mapping is now possible thanks to the technological advances of ChIP-chip and ChIP-seq. This Review discusses how recent genomic profiling of transcription factors gives insight into how binding specificity is achieved and what features of chromatin influence the ability of transcription factors to interact with the genome. It also suggests future experiments that may further our understanding of the causes and consequences of transcription factor-genome interactions.

MeSH Terms
Animals Binding Sites Chromosome Mapping/methods Consensus Sequence/genetics Gene Expression Profiling/methods Gene Expression Regulation/genetics Humans Models, Biological Transcription Factors/metabolism,physiology
Chemicals
Transcription Factors
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Farnham Peggy J
Department of Pharmacology and the Genome Center, University of California Davis, Davis, California 95616, USA. [email protected]
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Article Info
Journal
Nature reviews. Genetics
Abbr.
Nat Rev Genet
ISSN
1471-0064
DOI
10.1038/nrg2636
Email
[email protected]
Published
2009-09-00
Epub
2009-00-11
Pages
605-16
Language
English
Region
England
NLM ID
100962779
PMCID
PMC2846386
Subset
IM
Grants
NCI NIH HHS · R01 CA045240 · United States
NCI NIH HHS · R01 CA045240-23 · United States
NHGRI NIH HHS · U54 HG004558 · United States
NHGRI NIH HHS · U54 HG004558-03 · United States
External Links
PubMed source DOI: 10.1038/nrg2636 PMC Full Text View journal details
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