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PMID: 1967820 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Regulation of the mevalonate pathway.

Nature ·Vol. 343 ·No. 6257 ·1990-02-01 ·Pages 425-30

Goldstein JL, Brown MS

Abstract

The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mevalonate for several end-products. Manipulation of this regulatory system could be useful in treating certain forms of cancer as well as heart disease.

MeSH Terms

Animals Cell Division Cholesterol/biosynthesis Farnesol/metabolism Gene Expression Regulation/drug effects Humans Hydroxymethylglutaryl CoA Reductases/genetics Hydroxymethylglutaryl-CoA Synthase/genetics Mevalonic Acid/metabolism Receptors, LDL/genetics Sterols/pharmacology Transcription, Genetic/drug effects

Chemicals

Receptors, LDL Sterols Farnesol Cholesterol Hydroxymethylglutaryl CoA Reductases Hydroxymethylglutaryl-CoA Synthase Mevalonic Acid

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Goldstein J L

Departments of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235.

Brown M S

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/343425a0

Published

1990-02-01

Pages

425-30

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/343425a0 View journal details

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Regulation of the mevalonate pathway.

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